Office: U627

Tel：08-7624002 ext. 2627

E-mail: bear@tajen.edu.tw

Overall academic performance and ORCID information

ORCID: https://orcid.org/0000-0003-4674-3363. As of now (up to 2024/11/14), Dr. Bear has published a total of 46 academic papers. According to ORCID and Scopus preview information, the papers have been cited a total of 921 times across 893 SCI papers, with an h-index of 14 (https://orcid.org/0000-0003-4674-3363, Scopus Author ID: 54944623200). Dr. Bear has 16 patents granted or pending, and 6 of the research projects Dr. Bear participated in have been practically applied in the industry through technology transfer. Additionally, Dr. Bear has been involved in the application, coordination, execution, and completion of over 30 projects, including government projects and industry-academia collaboration projects.

Current positions

• Assistant professor, Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Taiwan.
• Director, Office of Institutional Research and Sustainable Development, Office of Secretariat, Tajen University, Taiwan.

Education

• Ph.D. in Pharmacy, Graduate Institute of Natural Products, Kaohsiung Medical University.

Employments and experiences

• 2016-2023: Postdoctoral researcher, Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan.
• 2019: Research abroad fellow, Faculty of Pharmacy, University of Szeged, Hungary.

 Experiences

• Pilot study of new botanic drugs, R&D on natural products and healthy foods.
• Supercritical fluid extraction, Instrumental analysis, Spectroscopy, Pharmaceutical analysis and pharmacognosy.

Association attended

• The Society of Chinese Natural Medicine, Life Member.
• The Pharmaceutical Society of Taiwan，Member​​​.
• 2024 Academic Committee Members, The Society of Chinese Natural Medicine.
• 2023 Academic Committee Members, The Society of Chinese Natural Medicine.

Award

• Outstanding Academic Award in Natural Products – Young Scholar Award, the 37th Symposium on Natural Products & the Ceremony in Honor of Late Academician Professor Kuo-Hsiung Lee - Nature is the Best Guide, 2022.

Publications

1. Ya-Ting Chuang, Ching-Yu Yen, Tsu-Ming Chien, Fang-Rong Chang, Yi-Hong Tsai, Kuo-Chuan Wu, Jen-Yang Tang, Hsueh-Wei Chang, 2024. “Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis.” Int. J. Mol. Sci., 25(11): 6083. (Impact factor = 4.9. Ranked Q1, Top 20.9% in BIOCHEMISTRY & MOLECULAR BIOLOGY - SCIE).
2. Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, Yang-Chang Wu, Fang-Rong Chang, István Szatmári, Ferenc Fülöp, 2024. “Synthesis of bioactive evodiamine and rutaecarpine analogues under a ball milling condition.” Org. Biomol. Chem., 22, 2620-2629. (Impact factor = 2.9. Ranked Q1, Top 21.6% in CHEMISTRY, ORGANIC - SCIE).
3. Yi-Hong Tsai¹, Yen Chi Loo¹, Hsieh Chen, Hui-Ping Hsieh, Yen-Chang Chen, Hsueh-Er Chen, Zhi-Hu Lin, Tse-Hung Huang, I-Min Liu, Chia-Ching Liaw, Fang-Rong Chang, 2024. “Quality and production enhancement of fish mint, Houttuynia cordata Thunb., cultivated in a hydroponic planting system with designed plant growth-promoting additives.” Heliyon, 10(7):e28755. (Impact factor = 3.4. Ranked Q1, Top 20.5% in MULTIDISCIPLINARY SCIENCES - SCIE). First author.
4. Ya-Ting Chuang, Ching-Yu Yen, Jen-Yang Tang, Fang-Rong Chang, Yi-Hong Tsai, Kuo-Chuan Wu, Tsu-Ming Chien, Hsueh-Wei Chang, 2024. “Protein phosphatase 2A modulation and connection with miRNAs and natural products.” Environ. Toxicol, 39(6):3612-3627. (Impact factor = 4.4. Ranked Q1 in TOXICOLOGY - SCIE).
5. Ya-Ting Chuang, Ching-Yu Yen, Jun-Ping Shiau, Fang-Rong Chang, Chang-Yih Duh, Ping-Jyun Sung, Kuan-Liang Chen, Yi-Hong Tsai, Jen-Yang Tang, Jiiang-Huei Jeng, Jyh-Horng Sheu, Hsueh-Wei Chang, 2024. “Demethoxymurrapanine, an indole-naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells.” Environ. Toxicol., 39(3), 1221–1234. (Impact factor = 4.4. Ranked Q1, Top 18% in TOXICOLOGY - SCIE).
6. Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Yi-Hong Tsai, Ammad Ahmad Farooqi, Hsueh-Wei Chang, 2023. “Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis.” Int. J. Mol. Sci., 24(15):12449. (Impact factor = 6.208. Ranked Q1, Top 23% in BIOCHEMISTRY & MOLECULAR BIOLOGY - SCIE).
7. Ya-Ting Chuang, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Fang-Rong Chang, Yi-Hong Tsai, Ching-Yu Yen, Hsueh-Wei Chang*, 2023. “Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products.” Cancers, 15(8), 2215. (Impact factor = 6.675. Ranked Q1, Top 24.29% in ONCOLOGY - SCIE).
8. Yen Chi Loo, Hao-Chun Hu, Szu-YinYu, Yi-Hong Tsai, Michal Korinek, Yang-ChangWu*, Fang-Rong Chang*, Ying-JungChen*, 2022. “Development on potential skin anti-aging agents of Cosmos caudatus Kunth via inhibition of collagenase, MMP-1 and MMP-3 activities.” Phytomedicine, 110:154643. (Impact factor = 6.655. Ranked Q1, No.1 in INTEGRATIVE & COMPLEMENTARY MEDICINE - SCIE).
9. Wei-Yu Fang, Chih-Lung Lin, Wan-Hsuan Chang, Chih-Hsiang Chang, Yun-Cian Huang, Yi-Hong Tsai, Fang-Rong Chang, Yi-Ching Lo*, 2022. “Protective effects of a chalcone-based derivative AN07 on inflammation-associated myotube atrophy induced by lipopolysaccharide.” Int. J. Mol. Sci., accepted, Int. J. Mol. Sci., 23(21):12929. (Impact factor = 6.208. Ranked Q1, Top 23% in BIOCHEMISTRY & MOLECULAR BIOLOGY - SCIE).
10. Wei-Yu Fang, Wan-Hsuan Chang, Yi-Hong Tsai, Hung-Te Hsu, Feng-Rong Chang, Chih-Lung Lin, Yi-Ching Lo*, 2022. “Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle.” J. Food Drug Anal., 31(1), Article 8. (Impact factor = 6.157. Ranked Q1, Top 16% in PHARMACOLOGY & PHARMACY - SCIE).
11. Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai*, Fang-Rong Chang*, 2022. “Composition decipherment of F. pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference.” J. Food Drug Anal., 30(3), Article 9. (Impact factor = 6.157. Ranked Q1, Top 16% in PHARMACOLOGY & PHARMACY - SCIE). Corresponding author.
12. Michal Korinek, Heba Handoussa, Olha Mykhailenko, Meng-Hua Chen, Zan-Wei Chiou, You-Ying Chen, Yi-Hong Tsai, Bing-Hung Chen, Mohamed El-Shazly, Tsong-Long Hwang*, 2021. “Antimicrobial and anti-inflammatory effects of volatile oils widely used in Mediterranean diet.” Free Radic. Biol. Med., 165(1), 38.
13. Wei-Kuang Lai, Yang-Chang Wu, Tai-Sheng Yeh, Chun-Ren Hsieh, Yi-Hong Tsai, Chien-Kei Wei, Chi-Ying Li, Ying-Chen Lu*, Fang-Rong Chang*, 2021. “The protoplast two-way fusions and fusant characteristics of Antrodia cinnamomea and Cordyceps militaris.” Food Sci. Hum. Wellness, 11(5), 1240-1251. (Impact factor = 8.022. Ranked Q1, Top 10% in NUTRITION & DIETETICS - SCIE).
14. Abdel Nasser B Singab, Nada M Mostafa, Yasmin A Elkhawas, Eman Al-Sayed, Mokhtar M Bishr, Ahmed M Elissawy, Mohamed S Elnaggar, Iten M Fawzy, Osama M Salama, Yi-Hong Tsai, Fang-Rong Chang*, 2021. “Cyclodepsipeptides: isolation from endophytic fungi of Sarcophyton ehrenbergi and verification of their larvicidal activity via in-vitro and in-silico studies.” Mar. Drugs., 20(5), 331. (Impact factor = 6.085, ranked Q1, Top 16% in CHEMISTRY, MEDICINAL - SCIE).
15. Yi-Hong Tsai, Fang-Rong Chang*, YangChang Wu*, 2022. “In memory of professor Kuo-Hsiung Lee (K. H. Lee).” J. Tradit. Complement. Med. 12(2), 217-218. (Impact factor = 4.221. Ranked Q2, top 27% in INTEGRATIVE & COMPLEMENTARY MEDICINE)). First author.
16. Chi-Jung Tai, Mohamed El-Shazly, Yi-Hsin Yang, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang*, 2022. “The effectiveness of Fuzi in combination with routine heart failure treatment on chronic heart failure patients” J. Ethnopharmacol., 289: 115040. (Impact factor = 5.195. Ranked Q1, Top 12.98% in INTEGRATIVE & COMPLEMENTARY MEDICINE - SCIE).
17. Chiao-Chih Huang, Tzu-Ching Lin, Chiung-Hui Liu, Hao-Chun Hu, Szu-Yin Yu, Shu-Jing Wu, Ming-Hong Yen, Yi-Hong Tsai*, Fang-Rong Chang*, 2021. “Lipid metabolism and its mechanism triggered by supercritical CO₂ extract of adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) bran in high fat diet-induced hyperlipidemic hamsters.” Front. Pharmacol., 12:785944. (Impact factor = 5.988. Ranked Q1, Top 18% in PHARMACOLOGY & PHARMACY - SCIE). Corresponding author.
18. Michal Korinek, Heba Handoussa, Yi-Hong Tsai, You-Ying Chen, Meng-Hua Chen, Zan-Wei Chiou, Yu Fang, Fang-Rong Chang, Chia-Hung Yen, Chung-Fan Hsieh, Bing-Hung Chen, Mohamed El-Shazly, Tsong-Long Hwang, 2021. “Anti-inflammatory and antimicrobial volatile oils: Fennel and cumin inhibit neutrophilic inflammation via regulating Calcium and MAPKs.” Front. Pharmacol., 12:674095. (Impact factor = 5.988. Ranked Q1, Top 18 in PHARMACOLOGY & PHARMACY - SCIE).
19. Kartiko Arif Purnomo, Michal Korinek, Yi-Hong Tsai, Hao-Chun Hu, Yi-Hsuan Wang, Anders Backlund, Tsong-Long Hwang, Bing-Hung Chen, Shih-Wei Wang, Chin-Chung Wu, Fang-Rong Chang*, 2021. “Decoding multiple biofunctions of maca on its anti-allergic, anti-inflammatory, anti-thrombotic, and pro-angiogenic activities.” J. Agri. Food Chem., 69(40):11856-11866. (Impact factor = 5.895. Ranked Q1, Top 10% in AGRICULTURE, MULTIDISCIPLINARY - SCIE).
20. Bernard S. Canusa, Ivan L. Lawag, Oliver B. Villaflores, Vitthal D. Wagh, Michal Korinek, Yi-Hong Tsai, Fang-Rong Chang, Ma. Alicia M. Aguinaldo*, 2021. “α-Glucosidase inhibitors from the bark extract of ethno-antidiabetic Ceriops tagal (Perr.) C.B. Rob” Philipp. J. Sci., 151 (S1): 25-60.
21. Yi-Hong Tsai¹, Hao-Chun Hu¹, Yu-Che Chuang, Kuei-Hung Lai, Yu-Ming Hsu, Tsong-Long Hwang, Chih-Chan Lin, Ferenc Fülöp, Yang-Chang Wu, Szu-Yin Yu, Yu-Ting Kuo*, Fang-Rong Chang*, 2021. “Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.” Nat. Prod. Res., 2021 Sep 9;1-11. (Impact factor = 2.861. Ranked Q2 in CHEMISTRY, APPLIED - SCIE). First author.
22. Ching-Chia Chang, Chi-Ying Li, Yi-Hong Tsai, Mohamed El-Shazly, Chien-Kei Wei, Zih-Jie Yang, Shu-Li Chen, Chin-Chung Wu, Yang-Chang Wu, Fang-Rong Chang *, 2021. “Bioactive polyketides from the pathogenic fungus of Epicoccum sorghinum.” Planta, 253(6):116. (Impact factor = 4.540. Ranked Q1, Top 17% in PLANT SCIENCES - SCIE).
23. Chi-Jung Tai, Mohamed El-Shazly, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang*, 2021. “Uncovering modern clinical applications of Fuzi and Fuzi-based formulas: A nationwide descriptive study with market basket analysis.” Front. Pharmacol., 12:674095. (Impact factor = 5.988. Ranked Q1, Top 18 in PHARMACOLOGY & PHARMACY - SCIE).
24. Tzu-Jung Yu, Yuan-Bin Cheng, Li-Ching Lin, Yi-Hong Tsai, Bo-Yi Yao, Jen-Yang Tang, Fang-Rong Chang, Chia-Hung Yen, Fu Ou-Yang, Hsueh-Wei Chang*, 2021. “Physalis peruviana-derived physapruin A (PHA) inhibits breast cancer cell proliferation and induces oxidative-stress-mediated apoptosis and DNA damage.” Antioxidants, 10(3):393. (Impact factor = 7.675. Ranked Q1, Top 6% in CHEMISTRY, MEDICINAL - SCIE).
25. Wei-Kuang Lai, Ying-Chen Lu, Chun-Ren Hsieh, Chien-Kei Wei, Yi-Hong Tsai, Fang-Rong Chang*, You Chan*, 2021. “Developing lactic acid bacteria as an oral healthy food.” Life-Basel, 11(4): 268. (Impact factor = 3.251. Ranked Q2 in BIOLOGY - SCIE).
26. Hao-Chun Hu, Chi-Ying Li, Yi-Hong Tsai, Dai-Yun Yang, Yang-Chang Wu, Tsong-Long Hwang, Shu-Li Chen, Ferenc Fülöp, Attila Hunyadi, Chia-Hung Yen, Yuan-Bin Cheng, Fang-Rong Chang*, 2020. “Secondary metabolites and bioactivities of Aspergillus ochraceopetaliformis isolated from Anthurium brownie.” ACS Omega, 5(33):20991-20999. (Impact factor = 4.132. Ranked Q2 in CHEMISTRY, MULTIDISCIPLINARY - SCIE).
27. Chi-Ying Li, Ching-Chia Chang, Yi-Hong Tsai, Mohamed El-Shazly, Chin-Chung Wu, Shih-Wei Wang, Tsong-Long Hwang, Chien-Kei Wei, Judit Hohmann, Zih-Jie Yang, Yuan-Bin Cheng, Yang-Chang Wu, Fang-Rong Chang*, 2020. “Anti-inflammatory, antiplatelet aggregation, and antiangiogenesis polyketides from Epicoccum sorghinum: Toward an understating of its biological activities and potential applications.” ACS Omega, 5(19), 11092–11099. (Impact factor = 4.132. Ranked Q2 in CHEMISTRY, MULTIDISCIPLINARY - SCIE).
28. Chih-Wen Chen, Chih-Fong Tsai, Yi-Hong Tsai, Yang-Chang Wu*, Fang-Rong Chang*, 2020. “Association rule mining for the ordered placement of traditional Chinese medicine containers: An experimental study.” Medicine, 99(18): e20090. (Impact factor = 1.817. Ranked Q3 in MEDICINE, GENERAL & INTERNAL – SCIE).
29. Chih‐Wen Chen, Yi‐Hong Tsai, Fang‐Rong Chang, Wei‐Chao, Lin*, 2020. “Ensemble feature selection in medical datasets: Combining filter, wrapper, and embedded feature selection results.” Expert Syst., e12553. (Impact factor = 2.812. Ranked Q2, Top 34% in COMPUTER SCIENCE, THEORY & METHODS - SCIE).
30. Yun-Chien Lai, Chi-Jung Tai¹, Mohamed El-Shazly, Yu-Che Chuang, Shu-Tuan Chiang, Yi-Hong Tsai, Dezső Csupor, Judith Hohmann, Yang-Chang Wu*, Fang-Rong Chang*, 2019. “Quantification and simplified detoxification investigation on Fuzi, root of Aconitum carmichaelii.” Nat. Prod. Commun., 14(10), 1-8.
31. Yu-Ting Tseng, Yi-Hong Tsai¸ Ferenc Fülöp, Fang‐Rong Chang, and Yi-Ching Lo*, 2019. “2-Iodo-4’-methoxychalcone attenuates methylglyoxal-induced neurotoxicity by activation of GLP-1 receptor and enhancement of neurotrophic signal, antioxidant defense and glyoxalase pathway.” Molecules, 24(12), 2249.
32. Hung Su, Kuan-Ting Liu, Bai-Hsiun Chen, Yen-Ping Lin, Yu-Min Jiang, Yi-Hong Tsai¸ Fang-Rong Chang, Jentaie Shiea*, Chi-Wei Lee*, 2019. “Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care.” J. Food Drug Anal., 27, 2, 415−427.
33. Chi-Ying Li, I-Wen Lo, Yen-Ping Hsueh, Yu-Ming Chung, Shih-Wei Wang, Michal Korinek, Yi-Hong Tsai¸ Yuan-Bin Cheng, Tsong-Long Hwang, Clay C. C. Wang, Fang-Rong Chang, Yang-Chang Wu, 2019. “Epigenetic manipulation induces the production of coumarin-type secondary metabolite from Arthrobotrys foliicola.” Isr. J. Chem., 59(5), 432-438.
34. Chi-Ting Hsieh, Fang-Rong Chang, Yi-Hong Tsai, Yang-Chang Wu and Tusty-Jiuan Hsieh*, 2018. “2-Bromo-4’-methoxychalcone and 2-iodo-4’-methoxychalcone prevent progression of hyperglycemia and obesity via 5’-adenosine-monophosphate-activated protein kinase in diet-induced obese mice.” Int. J. Mol. Sci., 19(9), 2763.
35. Yi-Hong Tsai¹, Chien-Kei Wei¹, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh*, and Fang-Rong Chang*, 2017. “6-Paradol and 6-shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-paradol reduces blood glucose in high-fat diet mice.” Int. J. Mol. Sci., 18(1), 168. First author.
36. Michal Korinek, Yi-Hong Tsai, Mohamed El-Shazly, Kuei-Hung Lai, Anders Backlund, Shou-Fang Wu, Wan-Chun Lai, Tung-Ying Wu, Shu-Li Chen, Yang-Chang Wu, Yuan-Bin Cheng, Tsong-Long Hwang*, Bing-Hung Chen*, and Fang-Rong Chang*, 2017. “Anti-allergic hydroxy fatty acids from Typhonium blumei explored through ChemGPS-NP.” Front. Pharmacol., 8, 356.
37. Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang-Rong Chang*, 2017. “Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa).” J. Food Drug Anal., 25(1), 187−196.
38. Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang-Rong Chang*, 2017. “Corrigendum to “Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa)” (Journal of Food and Drug Analysis (2017) 25(1) (S1021949816301697) (10.1016/j.jfda.2016.11.001))” J. Food Drug Anal., 25(3), 748−749.
39. Yi-Hong Tsai¹, Yuan-Bin Cheng¹, I-Wen Lo, Chen-Chang Haung, Yu-Chi Tsai, Ludger Beerhues, Mohamed El-Shazly, Ming-Feng Hou, Shyng-Shiou Yuan, Chin-Chung Wu, Fang-Rong Chang*, and Yang-Chang Wu*, 2015. “Pandalisines A and B, novel indolizidine alkaloids from the leaves of Pandanus utilis.” Bioorg. Med. Chem. Lett., 25, 4333–4336. First author.
40. Tung-Ying Wu, Ying-Chi Du, Yu-Ming Hsu, Chi-Yu Lu, Abdel Nasser B. Singab, Mohamed El-Shazly, Tsong-Long Hwang, Wan-Yu Lin, Kuei-Hung Lai, Mei-Chin Lu, Yi-Hong Tsai, Ming-Feng Hou, Tsai-Hui Du*, and Fang-Rong Chang*, 2013. “New approach to the characterization and quantification of Antrodia cinnamomea benzenoid components utilizing HPLC-PDA, qNMR and HPLC-tandem MS: Comparing the wild fruiting bodies and its artificial cultivated commercial products.” Food Res. Int., 51, 23−31.
41. Chia-Lin Lee, Tsong-Long Hwang, Wan-Jung He, Yi-Hong Tsai, Chiao-Ting Yen, Hsin-Fu Yen, Chao-Jung Chen, Wei-Yi Chang, Yang-Chang Wu, 2013. “Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum.” Phytochemistry, 95, 315-321.
42. Yi-Hong Tsai¹, Tusty-Jiuan Hsieh, Min-Chun Liao, Ying-Chi Du, Pei-Jung Lien, Chuan-Chia Sun, Fang-Rong Chang*, and Yang-Chang Wu*, 2012. “Anti-diabetic properties of non-polar Toona sinensis Roem. extract prepared by supercritical-CO₂ fluid.” Food Chem. Toxicol., 50, 779−789. First author.
43. Chi-Ting Hsieh, Tusty-Jiuan Hsieh, Mohamed El-Shazly, Da-Wei Chuang, Yi-Hong Tsai, Chiao-Ting Yen, Shou-Fang Wu, Yang-Chang Wu*, and Fang-Rong Chang*, 2012. “Synthesis of Chalcone Derivatives as Potential Anti-diabetic Agents.” Bioorg. Med. Chem. Lett., 22, 3912−3915.
44. Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Da-Wei Chuang, Yu-Ming Chung, Yi-Hong Tsai, Shou-Fang Wu, Michal Korinek, Ying-Chi Du, Chi-Ting Hsieh, Jeh-Jeng Wang*, and Fang-Rong Chang*, 2012. “Synthesis of carbamates by direct C–H bond activation of formamides.” Eur. J. Org. Chem., 34, 6760−6766.
45. Tusty-Jiuan Hsieh, Pei-Chen Hsieh, Yi-Hong Tsai, Chia-Fang Wu, Chia-Chu Liu, Ming-Yen Lin, Ming-Tsang Wu*, 2012. “Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.” Toxicol. Sci., 130(1), 17-32.
46. I-Min Liu, Wen-Jen Yu, Shorong-Shii Liou, Thing-Fong Tzeng, Yi-Hong Tsai, Juei-Tang Cheng*, 2006. “Role of alcohol in the induction of hepatic injury by chronic consumption of medicated wine.” J. Food Drug Anal., 15, 4, Article 4.

Granted and filing Patents

Technology transfers

1. Extract of Toona sinensis from supercritical fluid extraction for treating diabetes and metabolic diseases, the preparation method, and the use thereof. Taiwan patent: I492755. Patent Holder: Kaohsiung medical university. Current Assignee: We-Yu Applied Bio-tech Co., Ltd. Royalty: 300,000 NTD.
2. Extract of Toona sinensis from supercritical fluid extraction for treating diabetes and metabolic diseases, the preparation method, and the use thereof. China patent: I492755. Patent Holder: Kaohsiung medical university. Current Assignee: We-Yu Applied Bio-tech Co., Ltd. Royalty: 1,200,000 NTD.
3. Composition for treating diabetes and metabolic diseases and a preparation method thereof. Taiwan patent: I417088; USA patent: US9085520B2. Patent Holder: Kaohsiung medical university. Current Assignee: Oneness Biotech Co., Ltd. Royalty: 30,000,000 NTD (in millstones).
4. Multiple beneficial functions of maca as anti-allergic, anti-neutrophilic inflammatory, anti-thrombotic, and pro-angiogenic agents and use thereof. US patant: US 11,771,729 B2. Filing patants: Taiwan, Japan, and China patents. Patent Holder: Kaohsiung medical university. Current Assignee: Root & Stem Future biotechnology Co., Ltd. Royalty: 2,000,000 NTD.
5. Zink your heart drink. Patent Holder: Kaohsiung medical university. Current Assignee: Joben Bio-Medical Co., Ltd. Royalty: 1,000,000 NTD.
6. Vitality up Antrodia cinnamomea Drink. Patent Holder: Kaohsiung medical university. Current Assignee: Joben Bio-Medical Co., Ltd. Royalty: 1,000,000 NTD.

Project participation and conducts

1. Government funded projects (PI: Prof. Fang-Rong Chang):

1. National Science and Technology Council, NSTC (Ministry of Science and Technology, MOST) projects - Integrated project:

• R&D of precisely agricultural products in preventing cardiovascular risks and metabolic syndrome (111-2321-B-037 -004)，2022/07/01 ~ 2025/06/30。

2. NSTC (MOST) projects - General project:

• (Principal investigator, PI) NSTC-113-2320-B-127 -001，2024/08/01 ~ 2025/07/31.
• Using chemical and physical stimulations in genetic modulation for the development of fungal secondary metabolites (111-2320-B-037 -020 -MY3), 2022/08/01 ~ 2025/07/31.
• Natural products research and development under genetic and signaling expression modulation in fungi (MOST 108-2320-B-037-022-MY3) + Structure-Activity Relationship Investigation on Natural Products Produced by Epigenetically Manipulated Fungi – Innovational R&D of Medicinal Natural Products (MOST International Cooperation Add-on Project Application Form, Magic), 2019/08/01 ~ 2022/07/31.
• Epigenetic manipulation as a pathway to develop functional metabolites from fungi II (MOST 105-2628-B-037-001-MY3) + Semi- to total synthetic strategies for scaling up the functional metabolites from epigenetically manipulated fungus. (MOST International Cooperation Add-on Project Application Form, Magic),2016/08/01~2019/10/31.
• Research & Development on Anti-allergic Materials of Aquilaria malaccensis (MOST 106-2320-B-037-008-MY2), 2017/08/01~2019/07/31.
• Epigenetic manipulation as a pathway to develop functional metabolites from fungi (MOST 102-2628-B-037 -003-MY3), 2013/08/01 ~ 2016/07/31.

3. NSTC (MOST) projects - International cooperative projects (PI: Prof. Fang-Rong Chang):

• Chemical approaches in the quest for bioactive compounds IV. (2/2) - HAS-MOST Project-based Personnel Exchange Program, PPP between Ministry of Science and Technology, Taiwan and Hungarian Academy of Sciences, Hungary (MOST 111-2927-I-037-501), 2022/01/01 ~ 2022/12/31.
• Chemical approaches in the quest for bioactive compounds IV. (1/2) - HAS-MOST Project-based Personnel Exchange Program, PPP between Ministry of Science and Technology, Taiwan and Hungarian Academy of Sciences, Hungary (MOST 109-2927-I-037-502), 2020/11/01 ~ 2021/10/30.
• Chemical approaches in the quest for bioactive compounds III. (2/2) - HAS-MOST Project-based Personnel Exchange Program, PPP between Ministry of Science and Technology, Taiwan and Hungarian Academy of Sciences, Hungary (MOST 107-2911-I-037-502), 2018/05/01~2019/10/31.
• Chemical approaches in the quest for bioactive compounds III. (1/2) - HAS-MOST Project-based Personnel Exchange Program, PPP between Ministry of Science and Technology, Taiwan and Hungarian Academy of Sciences, Hungary (MOST 106-2911-I-037-504), 2017/01/01~2017/12/31.
• Chemical approaches in the quest for bioactive compounds II. (2/2) - HAS-MOST Project-based Personnel Exchange Program, PPP between Ministry of Science and Technology, Taiwan and Hungarian Academy of Sciences, Hungary, (MOST 105-2911-I-037-501), 2016/01/01~2016/12/31.

4. NSTC (MOST) projects - National R&D projects (PI: Prof. Yang-Chang Wu and Fang-Rong Chang):

• Drug Development of Novel Chalcone Derivatives against Diabetes and Metabolic syndrome (II), MOST 99-2323-B-037-002, 2010/10/01~2011/07/31.
• WYC-01 and WYC-02 New Drug Preclinical Research and Development, MOST 99-2323-B-039 -002, 2010/08/01 ~ 2011/07/31.
• Drug Development of Novel Chalcone Derivatives against Diabetes and Metabolic syndrome, MOST 98-2323-B-037-004, 2009/10/01 ~2010/10/31.

5. Agriculture and Food Agency, Council of Agriculture, Executive Yuan, Taiwan (PI: Prof. Fang-Rong Chang and Chia-Chung Chen):

• Establishment of Philippine Tropical Facility Base and Cooperative Development Program for Health Crop Products, 2017. 106農科-21.1.3-糧-Z2, 2017/01/01 ~ 2017/12/31 (New southbound policy).
• Establishment of Philippine Tropical Facility Base and Cooperative Development Program for Health Crop Products, 2018.107農科-17.1.3-糧-Z1, 2018/01/01 ~ 2018/12/31 (New southbound policy).

6. Small Business Innovation Research (SBIR) program & Conventional industry technology development (CiTD), Ministry of Economic Affairs, Taiwan (PI: Prof. Yang-Chang Wu and Fang-Rong Chang):

• The alliance project of application and development on highly value-added natural plant extract of Houttuynia cordata and its intelligent agriculture. We-Win bio-medical Co., Ltd., 2021/07/01 ~ 2022/06/30.
• Development of roselle seed oil for anti-allergic skin relief and skin care raw materials and products. We-Win bio-medical Co., Ltd., 2020/09/01 ~ 2021/07/31.
• Development project of agarwood seed oil for anti-allergic and anti-photoaging raw materials and products. We-Win bio-medical Co., Ltd., 2017/07/12 ~ 2018/07/11.
• The product development project of Taiwanese native green processed extract-supercritical Toona sinensis extract in anti-metabolic syndrome. We-Win bio-medical Co., Ltd., 2012/10/01 ~ 2013/06/30.
• The product development project of skin care and hypoglycemic products from Formosan thistle. Guang-Ding Biotech Co., Ltd., 2012/07/01 ~ 2012/12/31。

7. Metal Industries Research & Development Centre (MIRDC), Ministry of Economic Affairs, Taiwan (PI: Prof. Yang-Chang Wu and Fang-Rong Chang):

• Efficacy evaluation and mechanism investigation of Cinnamomoum osmophloeum and Toon sinensis extracts in improving metabolic syndrome, 2010/06/15 ~ 2010/11/30.
• Efficacy evaluation and mechanism investigation of Cinnamomum osmophloeum and Toona sinensis extracts in improving insulin resistance, 2008/09/22 ~ 2009/04/30.

2. Committee on Chinese Medicine and Pharmacy, Department of Health, Executive Yuan, Taiwan (PI: Prof. Yang-Chang Wu and Fang-Rong Chang):

• The process of the development of Chinese medicine – evaluation for the sources of the toxicity induced by the long-term or over – Doses administration of Chinese medicinal wines, CCMP95-CP-010, 1996.
• Promoting the safety research and education of Chinese medicine preparations – Investigation of the safety for the long-term administration of Chinese herbal alcohols, CCMP94-CP-013, 1995.

3. Academia-Industry co-operations (PI: Prof. Yang-Chang Wu and Fang-Rong Chang):

• (Principal investigator, PI) Development of a Drug Carrier-Hydrogel System for the Treatment of Tenosynovitis, Principal Investigator, Amount: 1,111,111 NTD, Tajen University/Min-Sheng Healthcare System, 2023/12/01-2024/11/30.
• R&D on the bioactivities of Taiwan endemic Aiyu extract, We-Win bio-medical Co., Ltd., 2022/06/15 ~ 2022/12/31.
• Research on a mullet material, Sea queenlet Co., Ltd., 2022/01/01 ~ 2022/12/31.
• Composition analyses of chemical markers in Houttuynia cordata, We-Win bio-medical Co., Ltd., 2021/11/01 ~ 2022/04/30.
• Isolation and identification of components from a natural plant, Jojia bio-tech co., Ltd., 2020/05/01 ~ 2021/12/31.
• R&D on a cosmetic mask, Nan Liu enterprise Co., Ltd., 2020/12/15 ~ 2021/12/15.
• Bio-active ingredients and optimal processes of roselle seed extracts, We-Win bio-medical Co., Ltd., 2020/11/01 ~ 2021/07/31.
• Antioxidant and antitumor active compositions from Juncus effusus, Chi mei medical center, 2014/05/01 ~ 2015/04/30.
• The product development project of Taiwanese native green processed extract – Product development of supercritical Toona sinensis extract for anti-metabolic syndrome. We-Win bio-medical Co., Ltd., 2012.
• Bioactivity evaluations of ginger extracts, Biotanico Inc., 2008/12/01 ~ 2010/05/31.
• Research project on chemical and biological activity profiles of Taiwan cultivated Salvia miltiorrhiza, YUF biotechnology Co. Ltd., 2009.
• Bioactivity Screening of Citrus maxima and Plectranthus amboinicus, Sinphar pharmaceutical co. ltd., 2008.

List of poster presentations in recent five years

1. The 38th Symposium on Natural Products—Insights into Natural Products from History & Symposium on Pharmacy and Traditional Chinese Medicine Presentation, 2023. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 27-239, 2023. “Advanced chemical and biological investigation of natural products from Andraca theae droppings.” Su-Chin Lin, Su-Li Chen, Mei-Chu Yang, Chein-Chen Su, Tsong-Long Hwang, Shih-Wei Wang, Yi-Hong Tsai*, Fang-Rong Chang*.
2. The 38th Symposium on Natural Products—Insights into Natural Products from History & Symposium on Pharmacy and Traditional Chinese Medicine Presentation, 2023. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 27-239, 2023. “Quality and production enhancement of fish mint, Houttuynia cordata Thunb., cultivated in a hydroponic planting system with designed plant growth-promoting additives.” Yi-Hong Tsai, Yen-Chi Loo, Pin-Chia Hwang, Chen-Hsieh, Hui-Pin Hsieh, Yen-Chang Chen, Shieh-Er Chen, I-Min Liu, Chia-Chin Liao, Fang-Rong Chang*.
3. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference.” Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien- Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai**, Fang-Rong Chang*.
4. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Analysis on Chemical Constituents of Taiwanese Reynoutria multiflora (Thunb.) Moldenke.” Yueh Yang, Cai-Qing Yin, Szu-Yin Yu, Hao-Chun Hu, Yi-Hong Tsai, Tsong-Long Hwang, Chia-Ching Liaw, Shu-Li Chen, Fang-Rong Chang*.
5. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.” Hao-Chun Hu¹, Yi-Hong Tsai¹, Kuang-Huang Wu, Yu-Che Chuang, Szu-Yin Yu, Yu-Ting Kuo, Tsong-Long Hwang, Ferenc Fülöp, Yang-Chang Wu, Fang-Rong Chang*.
6. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Development on potential skin anti-aging agents of Cosmos caudatus Kunth via inhibition of collagenase, MMP-1 and MMP-3 activities.” Yen Chi Loo, Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Michal Korinek, Yang- Chang Wu, Fang-Rong Chang*, Ying-Jung Chen*.
7. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti- inflammatory, Anti-thrombotic, and Pro-angiogenic Activities.” Kartiko Arif Purnomo, Michal Korinek, Yi-Hong Tsai, Hao-Chun Hu, Yi-Hsuan Wang, Anders Backlund, Tsong-Long Hwang, Bing-Hung Chen, Shih-Wei Wang, Chin- Chung Wu, Fang-Rong Chang*.
8. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “The Enhancing Effects of Water Extract of Guilu Erxian Jiao on Skeletal Muscle Mass and Function in C57BL/6J mice.” Wan-Hsuan Chang, Wei-Yu Fang, Yi-Hong Tsai, Fang-Rong Chang, Yi-Ching Lo*.
9. The 36th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2021. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 15-16, 2021. “Anti-allergic macapyrrolidones and macapyrrolins from maca explored through ChemGPS-NP.” Kartiko Arif Purnomo, Michal Korinek, Yi-Hong Tsai, Hao-Chun Hu, Anders Backlund, Bing-Hung Chen, Fang-Rong Chang.
10. The 35th Symposium of Natural Product and the 3rd Dr. Tsung Ming Tu medical forum, 2020. The Society of Chinese Natural Medicine, Taipei, Taiwan, September 11-13, 2020. “Bioactive components from Epicoccum sorhinum.” Ching-Chia Chang, Chi-Ying Li, Chien-Kei Wei, Yi-Hong Tsai, Yang-Chang Wu, Tsong-Long Hwang, Chin-Chung Wu, Shih-Wei Wang, Fang-Rong Chang.
11. The 34th Symposium of Natural Products 2019., The Society of Chinese Natural Medicine, Taoyuan, Taiwan, October 17-19, 2019. “Chemical constituents and bioactivities from the roots of Physalis peruviana.” Yu-Chi Lin, Bo-Yi Yao, Yi-Hong Tsai, Hao-Chun Hu, Tsong-Long Hwang, Fang-Rong Chang, Yuan-Bin Cheng.
12. The 34th Symposium of Natural Products 2019., The Society of Chinese Natural Medicine, Taoyuan, Taiwan, October 17-19, 2019. “Acylated flavonoid glycosides from the twigs and leaves of Gleditsia rolfei and Their Anti-influenza Activity.” Zie-Che Yang, Yi-Hong Tsai, Chia-Hung Yen, Fang-Rong Chang.
13. The 34th Symposium of Natural Products 2019., The Society of Chinese Natural Medicine, Taoyuan, Taiwan, October 17-19, 2019. “Research on the chemical constituents and bioactivities of Epicoccum sorghinum isolated from Arundo donax L.” Ching-Chia Chang, Chi-Ying Li, Chien-Kei Wei, Yi-Hong Tsai, Yang-Chang Wu, Tsong-Long Hwang, Chin-Chung Wu, Shih-Wei Wang, Fang-Rong Chang.
14. PSE-Young Scientists' Meeting 2019., Phytochemical Society of Europe, Budapest, June 19-22, 2019. “Development of traditional complex formulas as therapeutic agents.” Yi-Hong Tsai, Yu-Ting Tseng, Tung-Yin Wu and Yi-Ching Lo*, Fang-Rong Chang*.
15. American Society of Pharmacognosy 2019 Annual Meeting, Madison, Wisconsin, July 13-17, 2019. “Chemical and biological investigation of natural products from Epicoccum sorghinum.” Fang-Rong Chang*, Ching-Chia Chang, Chi-Ying Li, Yi-Hong Tsai, and Chien-Kei Wei.
16. The 17th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Kuching-Sarawak, Malaysia, August 8-10, 2018. “Deciphers on the Chemical Constituents and Biological Activities of the Fruiting Body of Cordyceps militaris.” Ching-Peng Chiu, Yi-Hong Tsai, Fang-Rong Chang.