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Ken-Ming Chang

中文  │ English

蔡逸宏助理教授

Ken-Ming Chang, Ph.D. / Assistant Professor
Tel: (886-8) 762-4002 ext 2833

 

Highest Education:

    Ph.D. in School of pharmacy, Kaohsiung Medical University

Current Positions:

   Tajen University, Department of Pharmacy, Project Assistant Professor

Email: q1600216@tajen.edu.tw

Experience:

1. Echochemical CO., LTD. Pharmacist 2006.01 - 2009.01
2. Tajen University, Department of Pharmacy, Adjunct Assistant Professor
    2018.08 - 2022.01
3. Heng Chun Christian Hospital, Director of Pharmacy 2019.03 - 2024.01
4. Meiho University, Department of Nursing, Adjunct Assistant Professor
     2022.08 - 2023.07
5. Federation of Taiwan Pharmacists Associations, Member of the Pharmacy
    Planning and Education Committee 2022.09 - NOW
6. Director of Ping Tung Pharmacist Association and Chairman of Pharmacist
    Continuing Education 2022.09 – 2024.05
7. Executive Director of Ping Tung Pharmacist Association and Chairman of
    Pharmacist Continuing Education 2024.05 - NOW

Teaching Course:

   Organic Chemistry Experiment, Medicinal Chemistry, Clinical
   Pharmacy, Pharmaceutical Analysis, Analytical Chemistry

Reseach Area:

  Medicinal Chemistry, Drug Design, Clinical Pharmacy

Paten:

1. 王泰吉、張耿銘、莊聲宏、曾誠齊、梁峰賓、陳意莉。萘倂呋喃衍生物及
    其製備方法與用於提升已產生抗藥性之癌細胞對化療藥物敏感性之應用 (
    發明專利字號: 第I534139號)。edicinal Chemistry, Drug Design, Clinical Pharmacy

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 Journal Papers

  1. Lin Hung-Yu, Tsai Tsen-Ni, Hsu Kai-Cheng, Hsu Yu-Ming, Chiang Lin-Chien, El-Shazly Mohamed, Chang Ken-Ming, Lin Yu-Hsuan, Tu Shang-Yi, Lin Tony Eight, Du Ying-Chi, Liu Yi-Chang and Lu Mei-Chin, From Sea to Science: Coral Aquaculture for Sustainable Anticancer Drug Development. Mar. Drugs, 2024, 22, 323.

  2. Lin H. Y.; Lin Y. S.; Shih S. P.; Lee S. B; El-Shazly M.; Chang K. M.; Yang Yu-Chen S. H.; Lee Y. L.; and Lu M. C. The Anti-Proliferative Activity of Secondary Metabolite from the Marine Streptomyces sp. against Prostate Cancer Cells. Life, 2021, 11, 1414.

  3. Chang K. M.; Chen L. C.; Tzeng C. C.; Lu Y. H.; Chen I. L.; Juang S. H.; Wang T. C. Synthesis and antiproliferative evaluation of oxime, methyloxime, and amide-containing quinazolinones. J. Chin. Chem. Soc. 2018, 65, 1110.

  4. Chang K. M.; Chen H. H.; Wang T. C.; Chen I. L.; Chen Y. T.; Yang S. C.; Chen Y. L.; Chang H. H.; Huang C. H.; Chang J. Y.; Shih C.; Kuo C. C.; Tzeng C. C. Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model. Eur. J. Med. Chem. 2015, 106, 60.

  5. Chang K. M.; Liang F. P.; Chen I. L.; Yang S. C.; Juang S. H; Wang T. C.; Chen Y. L.; Tzeng C. C. Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators. Bioorg. Med. Chem. 2015, 23, 3852.

  6. Chen C. L.; Chen I. L.; Chen J. J.; Wei D. C.; Hsien H. J.; Chang K. M; Tzeng C. C.; Wang, T. C. Studies on the alkylation of quinolin-2(1H)-one derivatives. J. Chil.Chem. Soc. 2015, 60, 2812.

  7. Chen L. C.; Juang S. H; Chang K. M.; Tzeng C. C.; Chen J. J.; Chen I. L.; Wang T. C. Synthesis and Antiproliferative Evaluation of Amide-Containing Anthraquinone, Xanthone, and Carbazole. Chem. Pharm. Bull. 2014, 62, 106.

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Conference

  1. Chang, Ken-Ming; Tsai, Tsen-Ni; Chen, Jian-Rong and Lu, Mei-Chin (November 4, 2024). 〝Sources of Targeted-Anticancer Candidates from Aquaculture Soft Coral〞2024全人醫療暨整合服務研討會暨國際論, Taichung, Taiwan. 

  2. Chang, K. M.; Lin, H. Y.; Liu, Y. C.; Chiang, L. C.; Tsai, T. N.; Lu, M. C (December 24-28, 2023). 〝Anti-prostate cancer mechanism of marine coral extract from Lobophytum crassum〞2023 The 29th FAPA Congress, Taipei, Taiwan.

  3. Chang, K. M.; Wang, T. C.; Wang, Y. Y.; Shih S. P.; Lu M. C. (November 6-7, 2021). 〝Antitumor Activity of 13-Acetoxysarcocrassolide, a Potent Dual Inhibitor of Hsp 90 and Topoisomerase IIα via Oxidative Stress〞 2021 The 3rd Taiwan Joint Conference of Pharmacy and Pharmaceutical Scienses – Advancing with AI technology through the pandemic, Tainan, Taiwan. (優秀論文獎)

  4. Luoz, I. L.; Chang, K. M.; Chen, J. Y.; Wei, D. C.; Chen I. L.; Wang, T. C. (December 17, 2016). 〝Design, synthesize and evaluate anticancer activity of ketone, oxime, and methyloxime containing anthraquinone derivatives〞 2016 Annual Symposium of The Pharmaceutical Society of Taiwan, Taipei, Taiwan.

  5. Chang, K. M.; Lu, Y. H.; Wei, D. C.; Chen, J. Y.; Chen I. L.; Juang, S. H; Wang, T. C. (August 29-31, 2016). 〝Synthesis and antiproliferative evaluation of oxime, methyloxime and amide-containing quinazoline derivatives〞 2016 PST Medicinal Chemistry Symposium, Kaohsiung, Taiwan.

  6. Chang, K. M.; Wang, T. C.; Kuo, C. C.; Chen, I. L.; Tzeng, C. C. (November 14, 2015). 〝Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model〞2015 Annual Symposium of The Pharmaceutical Society of Taiwan, Tainan, Taiwan.

  7. Chang, K. M.; Chen I. L.; Juang, S. H.; Liang, F. P.; Wang, T. C.; Tzeng, C. C. (May 31- June 2, 2015). 〝Synthesis and biological evaluation of oxime-bearing naphthalene derivatives〞 2015 PST Medicinal Chemistry Symposium, Nantou, Taiwan.

  8. Chang, K. M.; Chen, I. L.; Lin, Y. S.; Wang, P. Y.; Juang, S. H.; Wang, T. C.; Tzeng, C. C. (December 13, 2014).〝Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators〞2014 Annual Symposium of The Pharmaceutical Society of Taiwan, Kaohsiung, Taiwan.

  9. Chiou, M. S.; Chang, K. M.; Tseng, W. F.; Chen, J. J.; Wei, D. C.; Lu, Y. H.; Wang, T. C. (December 13, 2014).〝Design and synthesis of oxime, methyloxime, amide containing quinazoline derivatives and evaluation anti-proliferative activity〞2014 Annual Symposium of The Pharmaceutical Society of Taiwan, Kaohsiung, Taiwan.

  10. Chang, K. M.; Liang, F. P.; Juang, S. H.; Wang, T. C.; Tzeng, C. C. (January 21-23, 2014). 〝Synthesis of naphthol bearing oxime derivatives, and ability to evaluate cytoprotection by activation of Nrf2 signaling pathway〞 2014 PST Medicinal Chemistry Symposium, Hualien, Taiwan.

  11. Chang, K. M.; Chen, I. L.; Kuo, C. C.; Wang, T. C.; Tzeng, C. C. (December 14, 2013). 〝Synthesis and Invention of Coumarin Derivatives as a Novel Structural Type of Nrf2 Stimulation Agents〞2013 Annual Conference of The Pharmaceutical Society of Taiwan, Taipei, Taiwan.

  12. Chang, K. M.; Chen, J. J.; Wei, D. C.; Juang, S. H.; Fan, H. M.; Zheng, Y. T.; Chen I. L.; Wang, T. C. (January 22-24, 2013). 〝Synthesis and antiproliferative activities of N-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives〞2013 PST Medicinal Chemistry Symposium, Pingtung, Taiwan.

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