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Tai-Chi Wang

Name / Position

Tai-Chi Wang, Ph.D. / Professor

 

Office Address

No.20, Weixin Rd., Yanpu Township, Pingtung County 90741, Taiwan, R.O.C.

E-mail: tcwang@tajen.edu.tw

Tel: (886-8) 762-4002 ext 2833

  Fax: 08-7624002 # 5121

 王泰吉

 

Academic career

2004-

Professor, Department of Pharmacy, Tajen University 

1997-2004

 Associate Professor, Department of Pharmacy, Tajen University   

1986-1997

Lecturer, Department of Pharmacy, Tajen University

 

Education

Bachelor

Department of Pharmacy, China Medical University (1977-1982)

M.S.

Graduate Institute of Pharmacy, Kaohsiung Medical University (1982-1984)

Ph.D.

Graduate Institute of Pharmacy, Kaohsiung Medical University (1994-1999)

 

Teaching Courses

Organic Chemistry

Organic Synthesis Chemistry

Organic Chemistry Experiment

Medicinal Chemistry Experiment

Seminar

 

Research Area

Organic Chemistry

Medicinal Chemistry

Drug Design and Synthesis

  Natural product chemistry

 Publications

Refereed journals

  1. T. C. Wang, Y. L. Chen, C. C. Tzeng, S. S. Liou, Y. L. Chang and  C. M. Teng (1996). "Antiplatelet α-Methylene-γ-butyrolactone: Synthesis and Evaluation of Quinoline, Flavone, and Xanthone Derivatives", Helv. Chim. Acta., 79, 1620- 1626.(SCI).
  2. T. C. Wang, Y. L. Chen, K. H. Lee and C. C. Tzeng (1996). "An Intermolecular Michael Addition of Benzene", Tetrahedron Lett., 37, 6369-6370. (SCI) .
  3. Y. L. Chen, T. C. Wang, K. H. Lee, Y. L. Chang, C. M. Teng and C. C. Tzeng (1996). "Synthesis of Coumarin Derivative as Inhibitors of  Platelet Aggregation", Helv. Chim. Acta., 79, 651- 657. (SCI).
  4. Y. L. Chen, T. C. Wang, S. C. Liang, C. M. Teng and C. C. Tzeng (1996)." Synthesis and Evaluation of Coumarin α-Methylene-γ-butyrolactones : A New Class of Platelet Aggregation Inhibitors", Chem. Pharm. Bull., 44, 1591-1595. (SCI) .
  5. C. C. Tzeng, K. H. Lee, Y. L. Chen and T. C. Wang(1996). "Condensed 1, 2, 4- Triazine: Synthetic and Molecular Modeling Studies of 5,8-dihydro-7-methyl pyrazino[2,3-e]-1,2,4-triazines", Heterocycles, 43, 1007-1013.(SCI).
  6. T. C. Wang, Y. L. Chen, K. H. Lee and C. C. Tzeng (1997). "Lewis Acid- catalyzed Reaction of Cinnamanilides: Competition of Intramolecular and Intermolecular Friedel-Crafts reaction", Synthesis, 87-90. (SCI).
  7. C. C. Tzeng, T. C. Wang, Y. L. Chen, C. J. Wang, Y. L. Chang and C. M. Teng (1997). "Synthesis and Evaluation of 2-{[(2-Oxo-1H-quinolin-8-yl)oxy]methyl} substituted α-Methylidene-γ-butyrolactones", Helv. Chim. Acta., 80, 1161-1168. (SCI).
  8. T. C. Wang, Y. L. Chang and C. M. Teng (1997). " Synthesis and Evaluation of α- Methylidene-γ-butyrolactone Bearing Flavones and Xanthones", Helv. Chim. Acta., 80, 2337-2344. (SCI).
  9. Y. L. Chen, T. C. Wang, N. C. Chang, Y. L. Chang, C. M. Teng  and C. C. Tzeng (1998). "α-Methylene-γ-butyrolactones: Synthesis and Vasorelaxing Activity Assay of Coumarin, Naphthalene, and Quinoline Derivatives ", Chem. Pharm. Bull., 46, 962-965. (SCI).
  10. T. C. Wang, Y. L. Chen, C. C. Tzeng, S. S. Liou, W. F. Tzeng, Y. L. Chang and C. M. Teng (1998). "α-Methylidene-γ-butyrolactones: Synthesis and Evaluation of Quinolin-2(1H)-one Derivatives", Helv. Chim. Acta., 81, 1038- 1047. (SCI).
  11. T. C. Wang, K. H. Lee, Y. L. Chen, S. S. Liou and C.C. Tzeng (1998)."Synthesis and Anticancer Evaluation of Certain γ-Aryloxymethyl-α-methylene-γ- phenyl-γ-butyrolactones", Bioorg. Med. Chem. Lett., 8, 2773-2776. (SCI) .
  12. J.Y. Sheu, Y.L. Chen , K.C. Fang, T. C. Wang, C.F. Peng, and C.C. Tzeng (1998). "Synthesis and Antibacterial Activity of 1-(Substitutedbenzyl)-6-fluoro-1,4- dihydro-4-oxoquinoline-3-carboxylic Acids and their 6,8-Difluoro Analogs". Journal of Heterocyclic Chemistry, 35, 955-964. (SCI).
  13. Y. L. Chen, T. C. Wang, K. C. Fang, N. C. Chang, Y.L. Chang, C. M. Teng and C. C. Tzeng (1999). "α-Methylidene-γ-butyrolactones: Synthesis and Evaluation of 7-Substituted Quinolin-2(1H)-one Derivatives", Heterocycles, 50, 453-462. (SCI).
  14. T. C. Wang, C. C. Tzeng and N. C. Chang (1999). "Geiparvarin Analogues: Synthesis and Anticancer Evaluation  of α-Methylidene-γ-butyrolactone- Bearing Coumarins", Helv. Chim. Acta., 82, 191-197. (SCI).
  15. Y. L. Zhao, T. C. Wang, Y. L. Chen, Y. L. Chang, C. M. Teng and C. C. Tzeng
    (1999). "α-Methylene-γ-butyrolactones: Synthesis and Cardiovascular Evaluation of Flavone Derivatives", Chin. Pharm. J., 51, 49-63.
  16. I. L. Chen, T. C. Wang, Y. L. Chen,and C. C. Tzeng (2000). "Aluminum Chloride-Catalyzed Intermolecular vs Intramolecular Friedel-Crafts Reaction of Acrylanilides and 3-Chloropropanamides", J. Chin.Chem. Soc., 47, 155-162. (SCI) .
  17. C. C. Tzeng, T. C. Wang, I. L. Chen, Y. L. Chen, Y. L. Chang and C. M. Teng (2000). "Synthesis and Antiplatelet Activity Evaluation of α-Methylidene-γ- butyrolactones Bearing 3,4-Dihydroquinolin-2(1H)-one Moieties ", Helv. Chim. Acta, 83, 349-358. (SCI).
  18. Y. L. Chen, T. C. Wang, I. L. Chen and C. C. Tzeng (2000). "Synthesis and Cytotoxicity Evaluation of Certain α-Methylidene-γ-butyrolactones Bearing Coumarin, Flavone, Xanthone, Carbazole, and Dibenzofuran Moieties", Helv. Chim. Acta, 83, 989-994. (SCI).
  19. C. C. Tzeng, K. H. Lee, T. C. Wang, C. H. Han and Y. L. Chen (2000). "Synthesis and Cytotoxic Evaluation of A Series of γ-Substituted γ-Aryloxymethyl-α-methylene-γ-butyrolactones Against Cancer Cells", Pharm. Res., 17, 715-719. (SCI).
  20. K. C. Fang, Y. L. Chen, J. Y. Sheu, T. C. Wang and C. C. Tzeng (2000). "Synthesis, Antibacterial, and Cytotoxic Evaluation of Certain 7-Substituted Norfloxacin Derivatives". J. Med. Chem., 35, 955-964. (SCI).
  21. T. C. Wang*, Y. L. Zhao and D. H. Kuo (2001). "Synthesis and Vasorelaxing Evaluation of α-Methylene-γ-butyrolactone Quinolin-2(1H)-ones and 3,4-Dihydroquinolin-2(1H)-one Derivatives "Eur. J. Med. Chem., 36, 909-914. (SCI) NSC-89-2320-B-127-008.
  22. T. C. Wang*, Y. L. Zhao and S. S. Liou (2002). "Synthesis and Cytotoxic Evaluation of Potential Bis-Intercalators：Tetramethylene(oxy)- and Hexamethylene(oxy)- Linked Assemblies Consisting of Flavone, Xanthone, Anthraquinone, and Dibenzofuran ", Helv. Chim. Acta, 85, 1382-1389. (SCI) NSC-89-2320-B-127-008.
  23. I. L. Chen, Y. L. Chen, T. C. Wang, and C. C. Tzeng (2003). "Synthesis of Dibenzo[3,2-a]Quinoliniumum Perchlorates via Acid-Catalyzed Cyclization of 1-(2-Oxo-2- Phenylethyl)quinolin-2(1H)-ones ", Heterocycles, 1, 131-141.(SCI).
  24. J. Y. Sheu, Y. L. Chen, C. C. Tzeng, S. L. Hsu, K. C. Fang and T. C. Wang (2003). "Synthesis and Antimycobacterial and Cytotoxic Evaluation of Certain Fluoro quinolone derivatives", Helv. Chim. Acta, 86, 2481-2489. (SCI).
  25. T. C. Wang*, I. L. Chen, D. H. Kuo and C. H. Liao (2004). "Synthesis and Cytotoxic and Antiplatelet Activities of Dibenzofuran- and Carbazole-Substituted Oximes" Helv. Chim. Acta, 87, 983-990. (SCI). NSC 91-2320-B-127-005.
  26. Y. L. Zhao, Y. L. Chen, C. C. Tzeng, I. L. Chen, T. C. Wang and C. H. Han (2005). "Synthesis and Cytotoxic Evaluation of Certain 4-(Phenylamino)furo- [2,3-b]quinoline and 2-(Furan-2-yl)-4-(phenylamino)quinoline Derivatives" Chemistry＆Biodiversity, 2, 205-214. (SCI).
  27. T. C. Wang*, I. L. Chen, C. M. Lu, D. H. Kuo and C. H. Liao (2005). "Synthesis, and Cytotoxic and Antiplatelet Activities of Oxime- and Methyloxime-Containing Flavone, Isoflavone, and Xanthone derivatives" Chemistry＆Biodiversity, 2, 253-263. (SCI). NSC 92-2320-B-127-001.
  28. Y. L. Zhao, Y. L. Chen, J. Y. Sheu, I. L. Chen, T. C. Wang, Tzeng CC (2005). "Synthesis and Antimycobacterial Evaluation of Certain Fluoroquinolone Derivatives" Bioorg. Med. Chem., 13, 3921-3926. (SCI).
  29. Y. L. Chen, C. M. Lu, S. J. Lee, D. H. Kuo, I. L. Chen, T. C. Wang, C. C. Tzeng (2005). "Synthesis, Antiproliferative, and Vasorelaxing Evaluations of Coumarin α- Methylidene-γ-butrolactones" Bioorg. & Med. Chem., 13, 5710-5716. (SCI).
  30. Y. L. Chen, I. L. Chen, T. C. Wang, Han CH, Tzeng CC (2005). "Synthesis and Anticancer Evaluation of Certain 4-Anilinofuro[2,3-b]quinoline and 4-Anilinofuro [3,2-c]quinoline Derivatives" Eur. J. Med. Chem., 40, 928-934. (SCI).
  31. T. C. Wang, I. L. Chen, P. J. Lu, C. H. Wong, C. H. Liao, K. C. Tsiao, K. M. Chang, Y. L. Chen, and C. C. Tzeng(2005). "Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime- containing flavone and isoflavone derivatives" Bioorg. Med. Chem., 13, 6045-6053. (SCI). 93-2320-B-127-004
  32. J. J. Chen, S. Y. Huang, C. Y. Duh, I. S. Chen, T. C. Wang and H. Y. Fang (2006). "A New Cytotoxic Amide from the Stem Wood of Hibiscus tiliaceus", Planta. Med., 72, 935-938. (SCI).
  33. I. L. Chen, K. M. Chang, C. L. Miaw, C. H. Liao, J. J. Chen and T. C. Wang＊(2007). "Synthesis, antiproliferative, and antiplatelet activities of oxime- and amide- containing quinolin-2(1H)- one derivatives", Bioorg. Med. Chem., 15, 6527–6534. (SCI). NSC 94-2320-B-127-003
  34. J. J. Chen, Y. T. Luo, T. L. Hwang, P. J. Sung, T. C. Wang and I. S. Chen (2008). "A New Indole Alkaloid and Anti-inflammatory Constituents from Strychnos cathayensis", Chemistry & Biodiversity, 72, 1345-1352. (SCI).
  35. I. L. Chen, J.Y. Chen, P. C. Shieh, J. J. Chen, C. H. Lee, S. H. Juang and T. C. Wang＊(2008).  "Synthesis and Antiproliferative Evaluation of Amide-containing Flavone and Isoflavone Derivatives", Bioorg. Med. Chem., 16, 7639–7645. (SCI).
  36. T. H. Chou, I. S. Chen, T. L. Hwang, T. C. Wang, T. H. Lee, L. Y. Cheng, Y. C. Chang, J. Y. Cho and J. J. Chen (2008). "Phthalides from Pittosporum illicioides var. illicioides with Inhibitory Activity on Superoxide Generation and Elastase Release by Neutrophils", J. Nat. Prod., 71, 1692–1695. (SCI).
  37. J. J. Chen, S. S. Huang, C. H. Liao, D. C. Wei, P. J. Sung, T. C. Wang and M. J. Cheng (2009). "A New Phragmalin-type limonoid and anti-inflammatory constituents from the fruits of Swietenia macrophylla", Food Chemistry, 120, 379–384. (SCI).
  38. L. C. Chen, I. L. Chen, C. C. Huang, C. H. Liao, J. Y. Chen and T. C. Wang* (2010). "Synthesis, Antiproliferative, and Antiplatelet Activities of Oxime- containing 3,4-Dihydroquinolin-2(1H)-one Derivatives", Journal of the Chinese Chemical Society, 57, 1331-1340. (SCI).
  39. J. J. Chen*, Y. C. Tsai, T. L. Hwang and T. C. Wang (2011) "Thymol, Benzo- furanoid, and Phenylpropanoid Derivatives: Anti-inflammatory Constituents from Eupatorium cannabinum", J. Nat. Prod., 74, 1021–1027. (SCI).
  40. I. L. Chen, J. J. Chen, Y. C. Lin, C. T. Peng, S. H. Juang and T. C. Wang* (2013). "Synthesis and antiproliferative activities of N-(naphthalen-2-yl)acetamide and N- (substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3,4-dihydro quinolin- 2(1H)-one derivatives", European Journal of Medicinal Chemistry, 59, 227–234. (SCI).
  41. J. J. Chen*, T. C. Wang, C. K. Yang, H. R.Liao, P. J.Sung, I. S. Chen, M. J. Cheng, C. F. Peng and J. F. Cheng (2013). "New Pterosin Sesquiterpenes and Antitubercular Constituents from Pteris ensiformis", Chemistry & Biodiversity,  10, 1903-1908. (SCI).                                                              

 

  1. J. J. Chen*, C. W. Ting, Y. C. Wu, T. L. Hwang , M. J. Cheng, P. J. Sung, T. C. Wang and J. F. Chen (2013). "New Labdane-Type Diterpenoids and Anti-Inflammatory Constituents from Hedychium coronarium", International Journal of Molecular Sciences, 14, 13063-13077
  2. L. C. Chen,S.H. Juang, K. M. Chang, C. C. Tzeng, J. J. Chen, I. L. Chen and T. C. Wang*(2014). "Synthesis and Antiproliferative Evaluation of Amide-Containing Anthraquinone, Xanthone, and Carbazole", Chemical and Pharmaceutical Bulletin, 62, 106–111.   
  3. J. J. Chen*, M. J. Cheng, H. R. Liao, P. J. Sung, T. C. Wang, T. H. Chang and Y. P. Lim(2014)."Gmelinoiridoside, A New Iridoid Glycoside from Gmelina philippensis", Chemistry of Natural Compounds, 50, 1005–1008.  
  4. C. L. Chen, I. L. Chen, J. J. Chen, D. C. Wei, H. J. Hsieh, K. M. Chang, C. C. Tzeng and T. C. Wang*(2015). "Studies on the Alkylation of Quinolin- 2(1H)-one Derivatives", Journal of The Chilean Chemical Society, 60(1), 2248-2252.  
  5. J. J. Chen*, T. H. Lee, W. L. Kuo, P. J. Sung, I. S. Chen, C. W. Shu, M. J. Cheng, T. C. Wang, Y. P. Lim and R. Xu(2015). "(+)-(6aR,7R)-7-Hydroxy-N-Butyryl Caaverine, A New Aporphine Alkaloid From The Roots Of Illigera luzonensis With Cytotoxic Activity", Chemistry of Natural Compounds, 51 (4), 739-742.
  6. K. M. Chang, F. P. Liang, I. L. Chen, S. C. Yang, S. H. Juang , T. C. Wang*, Y. L. Chen and C. C. Tzeng(2015). "Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators”, Bioorganic & Medicinal Chemistry, 23, 3852–3859.
  7. C. Y. Chiang, T. C. Wang, C. H. Lee, C. S. Chen, S. H. Wang, Y. C. Lin and

S. H. Juang* (2015). "WTC-01, a novel synthetic oxime-flavone compound, destabilizes microtubules in human nasopharyngeal carcinoma cells in vitro   and in vivo", British Journal of Pharmacology, 172 (19), 4671–4683.

  1. H. H. Chen, T. C. Wang, Y. C. Lee, P. T. Shen, J. Y. Chang, T. K. Yeh, C. H. Huang, H. H. Chang, S. Y. Cheng, C. Y. Lin, C. Shih, C. T. Chen, W. M. Liu, C. H. Chen and C. C. Kuo* (2015). "Novel Nrf2/ARE Activator, trans-Coniferyl aldehyde, Induces a HO-1-Mediated Defense Mechanism through a Dual p38α/MAPKAPK‑2 and PK-N3 Signaling Pathway", Chemical Research in Toxicology, 28, 1681–1692.
  2. K. M. Chang, H. H. Chen, T. C. Wang, I. L. Chen, Y. T. Chen , S. C. Yang, Y. L. Chen, H. H. Chang, C. H. Huang, J. Y. Chang, C. Shih, C. C. Kuo and C. C. Tzeng* (2015). "Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model", European Journal of Medicinal Chemistry, 106 , 60–74.
  3. J. J. Chen*, W. L. Kuo, W. L. Kuo, H. R. Liao, Y. H. Kuo, I. S. Chen, C. W. Shu, P. J. Sung, Y. P. Lim, T. C. Wang and R. Xu(2017). "A new benzenoid and anti-inflamatory constituent of Capparis acutifolia", Chemistry of Natural Compounds, 53 (1), 21-23.
  4. J. J. Chen*, H. R. Liao, K. S. Chen, M. J. Cheng, C. W. Shu, P. J. Sung, Y. P. Lim, T. C. Wang and W. L. Kuo (2017). "A new 2H-Pyran-2-one derivative and anti- inflamatory constituent of Alpinia zerumbet", Chemistry of Natural Compounds, 53 (1), 40-43.

53. K. M. Chang, L.C. Chen, C. C. Tzeng, Y.H. Lu, I. L. Chen, S. H. Juang and T. C. Wang*(2018). "Synthesis and antiproliferative evaluation of oxime, methyloxime, and amide-containing quinazolinones", Journal of the Chinese Chemical Society 65, 1110-1118.

 

Conference Papers

1. Y. L. Chen , T. C. Wang, K. H. Lee, C. M. Teng , and C. C. Tzeng (November 1995). "Synthesis and Antiplatelet Evaluation of Coumarin Derivatives", Annual Meeting of Chinese Chemistry Society, Taichung, Taiwan.

2. T. C. Wang, Y. L. Chen , K. H. Lee, C. M. Teng , and C. C. Tzeng (December 1995). "α-Methylene-γ-butyrolactones: Synthesis and Antiplatelet Evaluation", Annual Meeting of Chinese Pharmaceutical Society, Taipei,Taiwan.

3. T. C. Wang, Y. L. Chen, K. H. Lee, D. C. Wei, K. C. Fang, C. M. Teng, and C. C. Tzeng ( March 1996). "Synthesis of Quinolinones as Potential Antiplatelet Agents", Annual Meeting on the Symposium of Medicinal Chemistry, Tainan, Taiwan.

4. C. C. Tzeng, T. C. Wang and Y. L. Chen (December 1996). "Synthesis of 2(1H)-Quinolinone α-Methylene-γ-butyrolactones as Potential Antiplatelet agents ", The Franco-Chinese Symposium on Organic and  Organometallic Chemistry, Strasbourg, France.

5. T. C. Wang, Y. L. Chen, K. C. Fang, J. Y. Sheu, Y. L. Zhao, S. P. Yang, and C. C. Tzeng (December 1996). "Lewis Acid-catalyzed Intermolecular Friedel-Crafts Reaction", Annual Meeting of Chinese Chemistry Society, Kaohsiung, Taiwan.   

6. T. C. Wang, Y. L. Chen, K. C. Fang, J. Y. Sheu, Y. L. Zhao, S. P. Yang, and C. C. Tzeng (December 1996). "Synthesis of 2(1H)-Quinolinone α-Methylene-γ- butyrolactones as Antiplatelet agents", Annual Meeting of Chinese Pharmaceutical Society, Taichung, Taiwan.

7. T. C. Wang, Y. L. Chen, K. C. Fang, J.Y. Sheu, Y.L. Zhao, S. P. Yang, and C. C. Tzeng (February 1997). "Synthesis of 8-Acetoxy-2-hydroxy-quinoline α- Methylene-γ-butyrolactones as Antiplatelet agents", Annual Meeting on the Symposium of Medicinal Chemistry, Kaohsiung, Taiwan.

  1. T. C. Wang and C. M. Teng (August 1997). "α-Methylene-γ-butyrolactones : Synthesis and Cardiovascular Evaluation of Coumarin, Naphthalene, Flavone and Quinoline Derivatives", 16th International Congress of Heterocyclic Chemistry, Montana State University, Bozeman, U. S. A.
  2. T. C. Wang, Y. L. Zhao, Y. L. Chen, C.J. Wang, C. C. Tzeng and C. M. Teng (September 1997). "Synthesis and Cardiovascular Evaluation of 2(1H)- Quinolinone α-Methylene-γ-butyrolactones", 12th Symposium on Natural Products, Kaohsiung, Taiwan.
  3. Y. L. Chen, T. C. Wang, N. C. Chang, C. M. Teng and C. C. Tzeng    (December 1997). "α-Methylene-γ-butyrolactones: Synthesis and Vasorelaxing Evaluation of Coumarin, Naphthalene and Quinoline Derivatives", Annual Meeting of Chinese Chemistry Society, Taipei, Taiwan.
  4. Y. L. Chen, T. C. Wang, C. C. Tzeng, and C. M. Teng (December 1997). " Quinolione α-Methylene-γ-butyrolactones: Synthesis and Cardiovascular Evaluation", 2th International Chemical Conference, Taipei-Chemical Synthesis, Taipei, Taiwan.
  5. T. C. Wang, Y. L. Chen,Y. L. Zhao, C. C. Tzeng, and C. M.Teng  (December 1997). "Synthesis and cardiovascular evaluation of  Quinolin-2(1H)-one α-Methylene-γ-butyrolactones", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  6. Y. L. Zhao, S. L. Hsu, T. C. Wang, Y. L. Chen, C. C. Tzeng, and C. M. Teng (December 1997). "α-Methylene-γ-butyrolactones: Synthesis and evaluation of Flavone and Xanthone derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  7. J. Y. Sheu, Y. L. Chen, K. C. Fang, T. C. Wang, C. C. Tzeng, and C. F. Peng (December 1997). "Synthesis and Antimicrobial activity of 1-Benzyl-1,4- dihydro-4-oxoquinolin-3-carboxylic acid", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  8. C. C. Tzeng, Y. L. Chen, K. H. Lee, and T. C. Wang (July 1998). "α- Methylene-γ-butyrolactones: Synthesis and Biological Evaluations", The First International Symposium for Chinese Medicinal Chemists, Taipei, Taiwan.
  9. T. C. Wang, Y. L. Chen, I. Li. Chen, and C. C. Tzeng (July 1998). "Synthesis and cardiovascular evaluation of Quinolin-2(1H)-one α-Methylene-γ-butyrolactones", The First International Symposium for Chinese Medicinal Chemists, Taipei, Taiwan.
  10. J. Y. Sheu, Y. L. Chen, K. C. Fang, T. C. Wang, C. F. Peng, and C. C. Tzeng (July 1998). "Synthesis and Antimicrobial activity of 1-(Substituted-Benzyl)- 6-fluoro-1,4-dihydro-4-oxoquinolin-3-carboxylicacids and their 8,6-difluoro analogs", The First International Symposium for Chinese Medicinal Chemists, Taipei, Taiwan.
  11. Y. L. Chen, T. C. Wang, and C. C. Tzeng (November 1998). "Geiparvarin Analogues: Synthesis and Anticancer Evaluation of α-Methylidene-γ-butyro lactone Bearing Coumarins", Annual Meeting of Chinese Chemistry Society, Chia-Yi, Taiwan.
  12. C. C. Tzeng, Y. L. Chen, and T. C. Wang (November 1998). " Geiparvarin Analogues: Synthesis and Antitumor Evaluation of  γ-Aryloxymethyl-α- methylene-γ-butyrolactones", International Symposium on Organic Reactions, Hsinchu, Taiwan.
  13. T. C. Wang, Y. L. Chen, K. C. Fang, J. Y. Sheu, Y. L. Zhao, and C.C. Tzeng (December 1998). "Synthesis and Anticancer Evaluation of Certain γ-Aryloxy methyl-α-methylene-γ-phenyl-γ-butyrolactones", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  14. Y. L. Zhao, T. C. Wang, Y. L. Chen, S. L. Hsu, I. L. Chen, C. M. Teng, and C. C. Tzeng (December 1998). "α-Methylene-γ-butyrolactones: Synthesis and Cardiovascular Evaluation of Flavone derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  15. T. C. Wang, K. H. Lee, Y. L. Chen, K. C. Fang, J. Y. Sheu, and C. C. Tzeng (May 1999). "Synthesis and Anticancer Evaluation of Certain γ-Substituted-γ- Aryloxymethyl-α-methylene-γ-butyrolactones", Annual Meeting on the Symposium of Medicinal Chemistry, Taichung, Taiwan.
  16. T. C. Wang, Y. L. Chen, S. L. Hsu, Y. L. Zhao, C. C. Tzeng, and C. M. Teng (May 1999). "Synthesis and Evaluation of 3,4-Dihydroquinolin-2(1H)-one α- Methylene-γ-butyrolactones", Annual Meeting on the Symposium of Medicinal Chemistry, Taichung, Taiwan.
  17. Y. L. Chen, T. C. Wang, I. L. Chen, and C. C. Tzeng (November 1999). "α- Methylene-γ-butyrolactones: Synthesis and Anticancer Evaluation of Coumarin, Carbazole, and Dibenzofuran", Annual Meeting of Chinese Chemistry Society, Taipei, Taiwan.
  18. K. C. Fang, Y. L. Chen, J. Y. Sheu, S. L. Hsu, T. C. Wang, and C. C. Tzeng (December 1999). "Synthesis, Cytotoxic, and Antibacterial Evaluation of Certain 7-Substituted Norfloxacin Derivatives", Annual Meeting of Chinese Pharmaceutical Society, Kaohsiung, Taiwan.
  19. I. L. Chen, T. C. Wang, Y. L. Chen, and C. C. Tzeng (December 1999). "Friedel- Crafts Reaction of Acrylanilides and 3-Chloropropanamides", Annual Meeting of Chinese Pharmaceutical Society, Kaohsiung, Taiwan.
  20. T. C. Wang, Y. L. Zhao, Y. L. Chen, I. L. Chen, C. C. Tzeng, and C. M. Teng (December 1999). "Synthesis and Antiplatelet Evaluation of 3,4-Dihydro- quinolin-2(1H)-one α-Methylene-γ-butyrolactones", Annual Meeting of Chinese Pharmaceutical Society, Kaohsiung, Taiwan.
  21. K. C. Fang, Y. L. Chen, J. Y. Sheu, S. L. Hsu, Y. L. Zhao, T. C. Wang, and C. C. Tzeng (July 2000). "Synthesis, Antibacterial, and Cytotoxic Evaluation of Certain 7-Substituted Norfloxacin Derivatives", Annual Meeting on the Symposium of Medicinal Chemistry, Pingtung, Taiwan.
  22. Y. L. Chen, I. L. Chen, C. C. Tzeng, C. H. Chung, P. H. Chen, and T. C. Wang (July 2000). "Certain α-Methylene-γ-butyrolactones Bearing Coumarins, Flavones, Xanthones, Carbazole, and Dibenzofuran Moieties", Annual Meeting on the Symposium of Medicinal Chemistry, Pingtung, Taiwan.
  23. C. C. Tzeng, K. H. Lee, T. C. Wang, C. H. Han, and Y. L. Chen (July 2000). "Synthesis and Cytotoxic Evaluation of A Series of γ-Substituted-γ-Aryloxy methyl-α-methylene-γ-butyrolactones Against Cancer Cells", Annual Meeting on the Symposium of Medicinal Chemistry, Pingtung, Taiwan.
  24. K. C. Fang, Y. L. Chen, J. Y. Sheu, T. C. Wang, and C. C. Tzeng (December 2000). "Synthesis, Antibacterial,and Cytotoxic Evaluation of Certain 7-Substituted 6-fluoroquinolones", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  25. I. L. Chen, T. C. Wang, Y. L. Chen, and C. C. Tzeng (November 2000). "Cytotoxicity Profile of α-Methylene-γ-butyrolactones Bearing Quinolin- 2(1H)-ones and 3,4-Dihydroquinolin-2(1H)-ones", Annual Meeting of Chinese Chemistry Society, Taichung, Taiwan.
  26. T. C. Wang, Y. L. Zhao, and D. H. Kuo (April 2001). "Synthesis and Vasorelaxing Evaluation of α-Methylene-γ-butyrolactone Quinolin-2(1H)-ones and 3,4-Dihydroquinolin-2(1H)-one Derivatives", Annual Meeting on the Symposium of Medicinal Chemistry, Hsinchu, Taiwan.
  27. T. C. Wang, Y. L. Zhao, and D. H. Kuo (December 2001). "3,4-Dihydro- quinolin-2(1H)-one α-Methylene-γ-butyrolactone Quinolin-2(1H)-ones: Synthesis and Vasorelaxing Evaluation", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  28. T. C. Wang, Y. L. Zhao, and S. S. Liou (February 2002). "Synthesis and Cytotoxic Evaluation of Tetramethylene- and Hexamethylene- Bridged Bis-Intercalators Consisting of Flavone, Xanthone, Anthraquinone, and Dibenzofuran", Annual Meeting on the Symposium of Medicinal Chemistry, Tainan, Taiwan.
  29. C. M. Lu, D. H. Kuo, B. H. Yang, and T. C. Wang (December 2002). " Vasorelaxing Effect of Synthetic Isoflavones", Annual Meeting of Chinese Pharmaceutical Society, Pingtung, Taiwan.
  30. T. C. Wang, D. H. Kuo, D. C. Wei, and B. H. Yang (December 2002). "Synthesis and Vasorelaxing Evaluation of Oximes Bearing Xanthone, Anthraquinone, Carbazole and Dibenzofuran", Annual Meeting of Chinese Pharmaceutical Society, Pingtung, Taiwan.
  31. T. C. Wang, I. L. Chen, D. H. Kuo, C. M. Lu, D. C. Wei, and C. H. Liao (December 2003). "Synthesis, Cytotoxic and Antiplatelet Activities of Oxime- containing Dibenzofuran and Carbazole derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  32. I. L. Chen, T. C. Wang, Y. L. Chen, and C. C. Tzeng (December 2003). "Synthesis and Anticancer Evaluation of Certain 4-anilinofuro[2,3-b]quinoline and 4-anilinofuro[3,2-c] quinoline derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  33. T. C. Wang, I. L. Chen, D. H. Kuo, D. C. Wei, and C. H. Liao (March 5-7, 2004). "Synthesis and Biological Activities of Oxime-containing Dibenzofuran and Carbazole Derivatives", 2004 PSCT Medicinal Chemistry Symposium, Kaohsiung, Taiwan.
  34. C. T. Chen, T. C. Wang, and C. H. Liao (April 2004). "Investigating the Antiplatelet effect of a Synthetic Compound F-7HQO", 2004 JBSC(19th) Symposium, Taipei, Taiwan.
  35. T. C. Wang, I. L. Chen, D. C. Wei, D. H. Kuo, C.H. Liao (November 18-22, 2004). "Synthesis, Cytotoxic, and Antiplatelet Activities of Oxime- and Methyloxime- Containing Flavone, Isoflavone, and Xanthone Derivatives", The Fourth International Symposium for Chinese Medicinal Chemists, Taipei.
  36. T. C. Wang, C. H. Han, and C. C. Tzeng (November 18-22, 2004). "Synthesis and Cytotoxic Evaluation of Certain 4-Anilinofuro[2,3-b]quinoline and 4-Anilino-2-furanylquinoline Derivatives", The Fourth International Symposium for Chinese Medicinal Chemists, Taipei.
  37. C. H. Tseng, Y. L. Chen, I. L. Chen, T. C. Wang, C. H. Han, and C. C. Tzeng (November 18-22, 2004). "Synthesis and Anticancer Evaluation of Certain 4-Anilinofuro[2,3-b]quinoline and 4-Anilinofuro[3,2-c]quinoline Derivatives", The Fourth International Symposium for Chinese Medicinal Chemists, Taipei.
  38. I. L. Chen, K. C. Tsiao, K. M. Chang, D. C. Wei, D. H. Kuo,C. H. Liao, and T. C. Wang* (December 18, 2004). " Synthesis and Biological Activities of Oxime- Containing Flavone, Isoflavone, and Xanthone Derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  39. I. L. Chen, K. C. Tsiao, K. M. Chang, D. C. Wei , P. J. Lu, C. H. Liao, and T. C. Wang* (September 4-6, 2005). "Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives", 2005 PSCT Medicinal Chemistry Symposium, Nantou, Taiwan.
  40. I. L. Chen, K. C. Tsiao, K. M. Chang, D. C. Wei , P. J. Lu, C. H. Liao, and T. C. Wang* (December 17-18, 2005). "Synthesis, antiproliferative, and antiplatelet activities of oxime-and methyloxime-containing flavone and isoflavone derivatives", Annual Meeting of Chinese Pharmaceutical Society, Tainan, Taiwan.
  41. I. L. Chen, K. M. Chang, K. C. Hsiao, D. C. Wei , C. H. Liao, and T. C. Wang* (August 23-25, 2006). "Synthesis and biological activities of oxime- and amide- containing quinolin-2(1H)-one", 2006 PSCT Medicinal Chemistry Symposium, Pingtung, Taiwan.
  42. I. L. Chen, K. M. Chang, M. H. Chen, C. H. Liao, and T. C. Wang* (November 2-7, 2006). "Synthesis and Antiplatelet Activity of Oxime- and Amide-Containing Quinolin-2(1H)-one Derivatives", The Fifth International Symposium for Chinese Medicinal Chemists, Nanjing, China.
  43. I. L. Chen, K. M. Chang, M. H. Chen, C. H. Liao, S. H. Juang, and T. C. Wang* (December 23, 2006). ²Synthesis, Antiproliferative, and Antiplatelet Activities of Oxime- and Amide-containing Quinolin-2(1H)-one², Annual Meeting of Chinese Pharmaceutical Society, Taichung, Taiwan.
  44. I. L. Chen, K. M. Chang, D. C. Wei , C. L. Miaw, P. J. Liao, S. H. Juang, and T. C. Wang* (December 23, 2006). ²Synthesis and Antiproliferative Activity of Amide-containing Flavone and Isoflavone Derivatives², Annual Meeting of Chinese Pharmaceutical Society, Taichung, Taiwan.
  45. I. L. Chen, K. M. Chang, J. Y. Chen, D. C. Wei, C. H. Liao, and T. C. Wang* (May 18-20, 2007). "Synthesis, Antiproliferative, Antimycobacterial, and Antiplatelet Activities of Oxime- and Amide-containing Quinolin-2(1H)-one Derivatives", 2007 TPA Medicinal Chemistry Symposium, Nantou, Taiwan.
  46. I. L. Chen, K. M. Chang, C. C. Huang, H. J. Hsieh, P. J. Liao, S. H. Juang, and T. C. Wang* ( May 18-20, 2007). “Synthesis and Cytotoxic Evaluation of Amide- containing Flavone and Isoflavone Derivatives”, 2007 TPA Medicinal Chemistry Symposium, Nantou, Taiwan.
  47. I. L. Chen, K. M. Chang, J. Y. Chen, M. H. Chen, C. H. Liao, and T. C. Wang* (December 8, 2007). ²Synthesis, Antiproliferative, Antimycobacterial, and Antiplatelet Activities of Oxime- and Amide-containing Quinolin-2(1H)-one Derivatives², Annual Meeting of Chinese Pharmaceutical Society, Kaohsiung, Taiwan.
  48. I. L. Chen, C. C. Huang, K. M. Chang, P. C. Shieh, S. H. Juang, and T. C. Wang* (December 8, 2007). ²Synthesis and Antiproliferative Activity of Amide- containing Flavone and Isoflavone Derivatives², Annual Meeting of Chinese Pharmaceutical Society, Kaohsiung, Taiwan.
  49. D. C. Wei, H. J. Hsieh, K. M. Chang, J. Y. Chen, I. L. Chen, and T. C. Wang* (December 8, 2007). ²Selective Alkylation of Quinolin-2(1H)-one Derivatives², Annual Meeting of Chinese Pharmaceutical Society, Kaohsiung, Taiwan.
  50. Y. C. Yang, C. H. Lee, T. C. Wang, M. Y. Chen, and S. H. Juang* (January 23-25, 2008). ²The Study of a New Leukemia-specific Antiproliferative Quinolinone Derivatives², Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology, Pingtung, Taiwan.
  51. C. H. Lee, T. C. Wang, I. L. Chen, M. Y. Chen, and S. H. Juang* (January 23-25, 2008). ²The Study of Antiproliferative Mechanism of de Novo Polyphenol Derivatives², Sixteenth Symposium on Recent Advances in Cellular and Molecular Biology, Pingtung, Taiwan.
  52. I. L. Chen, C. C. Huang, J. Y. Chen, P. C. Shieh, S. H Juang, and T. C. Wang* (April 25-27, 2008). "Synthesis and Antiproliferative Activity of Amide- containing 3,4-Dihydroquinolin-2(1H)-one Derivatives", 2008 PST Medicinal Chemistry Symposium, Nantou, Taiwan.
  53. I. L. Chen, C. C. Huang, J. Y. Chen, P. C. Shieh, S. H Juang, and T. C. Wang* ( April 25-27, 2008). "Selective Alkylation of Quinolin-2(1H)-one Derivatives", 2008 PST Medicinal Chemistry Symposium, Nantou, Taiwan.
  54. I. L. Chen, J. Y. Chen, S. H. Chen, S. H. Juang, and T. C. Wang* (July 28, 2008). "Synthesis and Antiproliferative Evaluation of Amide-containing Flavone and Isoflavone Derivatives" The 6th International Symposium for Chinese Medicinal Chemists, Shanghai.
  55. I. L. Chen, J. Y. Chen, S. H. Chen, S. H. Juang, and T. C. Wang* (November 22, 2008). "Synthesis and Antiproliferative Evaluation of Amide- and Oxime- containing Flavone and Isoflavone Derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  56. S. H. Juang, Y. C. Yang, C. H. Lee, Y. C. Lin, C. C. Kuo, and T. C. Wang (April 18-22, 2009). "HQO-0601, an amide-containing 3,4-Dihydroquinolinone Derivative, against human hematologic malignancies through inhibition of mammalian target of rapamycin signaling pathway", 100th Annual Meeting 2009 American Association for Cancer Research, Denver, Colorado, USA.
  57. S. H. Chen, I. L. Chen, J. Y. Chen, S. H. Juang, and T. C. Wang*(June 28-30, 2009). "Synthesis and Antiproliferative Activity of Amide-containing 3,4- Dihydroquinolin-2(1H)-one Derivatives", 2008 PST Medicinal Chemistry Symposium, Nantou, Taiwan.
  58. K. M. Chang, S. H. Chen, I. L. Chen, J. Y. Chen, D. C. Wei, C. H. Liao, and T. C. Wang* (June 28-30, 2009). "Synthesis and Evaluation Biological Activities of Oxime-containing 3,4-Dihydroquinolin-2(1H)-one Derivatives", 2008 PST Medicinal Chemistry Symposium, Nantou, Taiwan.
  59. B. J. Lin, T. C. Wang, J. Y. Chen, C. H. Liao, and I. L. Chen (June 28-30, 2009). "Synthesis and Biological Evaluation of 2-Methylfuro[3,2-h]quinoline and 8-Methylfuro[2,3-h]quinoline Derivatives", 2008 PST Medicinal Chemistry Symposium, Nantou, Taiwan.
  60. S. H. Juang, C. H. Lee, Y. C. Lin, C. Y. Chaing, and T. C. Wang (November 15-19, 2009). "A novel oxime-containing flavone anticancer agent, WTC01, exhibits potent microtubule disruption ability", AACR-NCI-EORTC International Conference, Boston, Colorado, USA.
  61. S. H. Chen, K. M. Chang, I. L. Chen, J. Y. Chen, C. H. Liao, and T. C. Wang* (November 28, 2009). "Synthesis, Antiproliferative, and Antiplatelet Activities Activity of Oxime-containing 3,4-Dihydroquinolin-2(1H)-one Derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  62. K. M. Chang, C. C. Tzeng, S. C. Yang, D. C. Wei, H. J. Hsieh, J. Y. Chen, and T. C. Wang* (November 28, 2009). “Studies on the Alkylation of Quinolin-2(1H)- one Derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  63. K. M. Chang, C. C. Tzeng, S. C. Yang, H. J. Hsieh, J. Y. Chen, and T. C. Wang* (December 5-6, 2009). "Studies on the Alkylation of Quinolin-2(1H)-one Derivatives ", Annual Meeting of Chemical Society, Kaoshiung, Taiwan.
  64. I. L. Chen, B. J. Lin, J. Y. Chen, C. H. Liao, and T. C. Wang* (February 1-5, 2010). "Synthesis and Biological Evaluation of Furo[3,2-h]quinoline and Furo[2,3-h] quinoline Derivatives", The 7th International Symposium for Chinese Medicinal Chemists, Kaoshiung, Taiwan.
  65. C. H. Lee, T. C. Wang, B. Y. Liu, C. H. Chen, and S. H. Juang (February 1-5, 2010). "The Mechanism Study of a de novo oxime-containing flavonoid Derivatives, WTC-01, Against Human Nasolpharyngeal Carcinoma Cells", The 7th International Symposium for Chinese Medicinal Chemists, Kaoshiung, Taiwan.
  66. I. L. Chen, J. Y. Chen, C. C. Huang, C. H. Liao, J. J. Chen, and T. C. Wang* ( February 1-5, 2010). "Synthesis and Biological Evaluation Activity of Oxime- containing 3,4-Dihydroquinolin-2(1H)-one Derivatives", The 7th International Symposium for Chinese Medicinal Chemists, Kaoshiung, Taiwan.
  67. K. M. Chang, T. C. Wang, I. L. Chen, J. Y. Chen, and C. C. Tzeng * (December 11, 2010). "Synthesis and Biological Evaluation of Oxime- and Amide-containing Coumarin Derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  68. Y. T. Tsai, I. L. Chen, J. Y. Chen, K. M. Chang, S. H. Juang, and T. C. Wang * (December 11, 2010). "Synthesis and Antiproliferative Activity of Amide- containing Anthraquinone, Xanthone and Carbazole Derivatives", Annual Meeting of Chinese Pharmaceutical Society, Taipei, Taiwan.
  69. I. L. Chen, J. Y. Chen, K. M. Chang, S. H. Juang, and T. C. Wang * (April 3-5, 2011). "Synthesis and Antiproliferative Activity of Amide-containing Anthraquinone, Xanthone and Carbazole Derivatives", 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions and PST Medicinal Chemistry Symposium, Nantou, Taiwan.
  70. K. M. Chang, T. C. Wang, I. L. Chen, and C. C. Tzeng* (April 3-5, 2011). "Synthesis and Biological Evaluation of Oxime- and Amide- containing Coumarin Derivatives", 2011 Taiwanese-Russian Organic, Medicinal and Bio Chemistry Interactions and PST Medicinal Chemistry Symposium, Nantou, Taiwan.
  71. S. H. Juang, C. H. Lee, Y. C. Lin, C. Y. Chaing, and T. C. Wang (May 22-25, 2011). "A Novel Oxime-containing Flavone, WTC-01, Exhibits Potent Anticancer Potential through Disruption of Microtubule by Binding to the Colchicine Binding Site of Tubulin in Human Nasopharyngeal Carcinomas", 2011 BITS 4th Annual World Cancer Congress, Dalian, China.
  72.  J. Y. Chen , I. L. Chen, D. C. Wei, K. M. Chang, S. H. Juang, and T. C. Wang * (October 29-30, 2011). "Evaluation the Antiproliferative Activity of Anthraquinone, Xanthone and Carbazole Derivatives", International Symposium on Traditional Chinese Medicine 2011＆ the 26th Symposium on Natural Products, Taichung, Taiwan.
  73. J. Y. Chen , I. L. Chen, D. C. Wei, K. M. Chang, S. H. Juang, and T. C. Wang * (December 3, 2011). "Evaluation the Antiproliferative Activity of Anthraquinone, Xanthone and Carbazole Derivatives", 2011 Annual Congress of the Pharmaceutical Society of Taiwan, Pingtung, Taiwan.
  74. K. M. Chang, I. L. Chen, J. Y. Chen, D. C. Wei, T. C. Wang*, and C. C. Tzeng* (December 3, 2011). "Biological Evaluation of Oxime- and Amide-containing Coumarin Derivatives", 2011 Annual Congress of the Pharmaceutical Society of Taiwan, Pingtung, Taiwan.                                                         

 

82. P. H. Tu, S. U. Jau, F. P. L, T. C. Wang, and Shin-Hun Juang*(March 17-18, 2012). "Quinazoline Derivative, QA-0305am, Showed Anti-Proliferation Ability on Nasopharyngeal Cancer (NPC-TW01)", 2012 The 27th joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

83. M. T. Lin, C. H. Lee, F. P. Liang, T. C. Wang, and S. H Juang*(March 17-18, 2012). "The role of Cytotoxicity agent WTC-01 on histone modification", 2012 The 27th joint Annual Conference of Biomedical Sciences, Taipei, Taiwan.

84. S. H. Wang, C. H. Lee, F. P. Liang, T. C. Wang, and S. H Juang*(May 5-7, 2012). "WTC-01 Microtubule disruption with histone modification", 2012 TPST Medicinal Chemistry Symposium, Nantou, Taiwan.

85. S. H Juang*, C. H. Lee, Y. C. Lin, and T. C. Wang* (June 8-11, 2012). "The Antiproliferative Mechanisms Studies of a De Novo Flavone-derivatives Agaunst Human Nasopharyngeal Carcinoma", The 3th Cross-Straits Symposium Progress in Pharceutical Sciences, Zhejiang, China.

86. S. H Juang*, C. H. Lee, Y. C. Lin, and T. C. Wang (August 25-29, 2012). “The Structure-activity Relationship and Antiproliferative Mechanisms of a De Novo Oxime-containing Flavone Antitumor Agent", 8th International Symposium for Chinese Medicinal Chemists, Beijing, China.

87. T. C. Wang, M. H. Chen, S. H Juang, D. H. Kuo, and I. L. Chen* (August 25-29, 2012). "Synthesis and Biological Evaluation of 8-Substituted Flavone and Isoflavone Derivatives", 8th International Symposium for Chinese Medicinal Chemists, Beijing, China.

88. K. M. Chang, J. Y. Chen, D. C. Wei, S. H. Juang, H. M. Fan, Y. T. Cheng, I. L. Chen*, and T. C. Wang* (November 25, 2012). "Synthesis and Antiproliferative Activity of Amide-containing Quinolin-2(1H)-one and 3,4-Dihydroquinolin- 2(1H)-one Derivatives", 2012 Annual Conference of the Pharmaceutical Society of Taiwan,, Taichung, Taiwan.

89. K. M. Chang, J. Y. Chen, D. C. Wei, S. H. Juang, Y. H. Tang, I. L. Chen*, and T. C. Wang* (November 25, 2012). "Evaluation the Antiproliferative Activity of Amide-containing Anthraquinone, Xanthone and Carbazole Derivatives", 2012 Annual Conference of the Pharmaceutical Society of Taiwan, Taichung, Taiwan.

90. K. M. Chang, J. Y. Chen, D. C. Wei, S. H.Juang, H. M. Fan, Y. T.Cheng, I. L. Chen *, and T. C.Wang*( January 22-24, 2013). "Synthesis and antiproliferative activities of N-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives", 2013 PST Medicinal Chemistry Symposium, Pingtung, Taiwan.

91. T. C. Chen, M. C. Hung, K. M. Chang, T. C. Wang, P. C. Shieh, F. A. Chen, I. L. Chen, Y. J. Tsai, and D. H. Kuo*( January 22-24, 2013). "Xanthine oxidase inhibition effect of different fermentation periods of Noni fruit and fresh fruit extract", 2013 PST Medicinal Chemistry Symposium, Pingtung, Taiwan.

92. Y. N. Juan, F. P. Liang, K. M. Chang, T. C. Wang*, and S. H. Juang*(January 22-24, 2013). "A naphthol-oxime derivative, Naph-O204, activates the Nrf2/ARE pathway and reduces intracellular oxidative stress through an Akt-dependent manner", 2013 PST Medicinal Chemistry Symposium, Pingtung, Taiwan.

93. J. P. Yang, K. M. Chang, J. Y. Chen, D. C. Wei, S. H. Juang, Y. L. Ding, Y. H. Tang, I. L. Chen*, and T. C. Wang*( January 22-24, 2013). "Synthesis and Antiproliferative Evaluation of N-(naphthalen-2-yl)acetamide and N-(substituted phenyl)acetamide bearing Anthraquinone, Xanthone, and Carbazole derivatives", 2013 PST Medicinal Chemistry Symposium, Pingtung, Taiwan.

94. K. M. Chang, I. L. Chen, C. C. Kuo, T. C. Wang* and C. C. Tzeng* (December 14, 2013). "Synthesis and Invention of Coumarin Derivatives as a Novel Structural Type of Nrf2 Stimulation Agents", 2013 Annual Conference of the Pharmaceutical Society of Taiwan, Taipei, Taiwan.

95. S. L. Chou, I. L. Chen, K. M. Chang, S. H. Juang and T. C. Wang *(December 14, 2013). "Synthesis Quinazoline Derivatives and Evaluation Anti-Proliferation Ability on Nasopharyngeal Cancer (NPC-TW01)", 2013 Annual Conference of the Pharmaceutical Society of Taiwan, Taipei, Taiwan.

96. C. T. Chai, K. M. Chang, J. Y. Chen, D. C. Wei, S. H. Juang, I. L. Chen and T. C. Wang* (December 14, 2013). "Synthesis and Anti-proliferative Evaluation of Amide-Containing Anthraquinone, Xanthone, and Carbazole", 2013 Annual Conference of the Pharmaceutical Society of Taiwan, Taipei, Taiwan.

97. K. M. Chang, F. P. Liang, S. H. Juang, T. C. Wang* and C. C. Tzeng* ( January 21-23, 2014). "Synthesis of naphthol bearing oxime derivatives, and ability to evaluate cytoprotection by activation of Nrf2 signaling pathway", 2014 PST Medicinal Chemistry Symposium, Hualien, Taiwan.

98. S. L. Chou, T. C. Wang, K. M. Chang, S. H. Juang and I. L. Chen * ( January 21-23, 2014). "Synthesis and Antiproliferative Evaluation of Quinazoline bearing -Oxime, -Methyloxime, and -Amide Derivatives", 2014 PST Medicinal Chemistry Symposium, Hualien, Taiwan.

99. Y. H. Lu, J. Y. Chen, D. C. Wei, K. M. Chang and T. C. Wang* ( September 27-28, 2014). "Modification and Evaluation Anti-Proliferation activities of Quinazoline Derivatives", The 29th Symposium on Natural Products, Kaoshiung, Taiwan.

100. K. M. Chang, I. L. Chen, Y. S. Lin, P. Y. Wang, S. H. Juang, T. C. Wang* and C. C. Tzeng* (December 13, 2014). "Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators", 2014 Annual Symposium of the Pharmaceutical Society of Taiwan, Kaoshiung, Taiwan.

101. M. H. Chiu, K. M. Chang, W. F. Tzeng, J. Y. Chen, D. C. Wei,, Y. H. Lu and T. C. Wang* (December 13, 2014). “Design and Synthesis of oxime, methyloxime, amide containing quinazoline derivatives and evaluation anti-proliferative activity", 2014 Annual Symposium of the Pharmaceutical Society of Taiwan, Kaoshiung, Taiwan.

102. K. M. Chang, I. L. Chen and T. C. Wang* (May 23, 2015). "Novel oxime- bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model", 2015 中國化學會高雄分會年會, Pingtung, Taiwan.

103. K. M. Chang, I. L. Chen, S. H. Juang, F. P. Liang, T. C. Wang* and C. C. Tzeng*  (May 23, 2015). "Synthesis and Biological Evaluation of oxime-bearing naphthalene derivatives", 2015 中國化學會高雄分會年會, Pingtung, Taiwan.

104. K. M. Chang, I. L. Chen, S. H. Juang, F. P. Liang, T. C. Wang* and C. C. Tzeng* (May 31, 2015). "Synthesis and Biological Evaluation of oxime-bearing naphthalene derivatives", 2015 PST Medicinal Chemistry Symposium, Nantou, Taiwan.

105. C. C. Tsai, K. M. Chang, D. C. Wei, J. Y. Chen, I. L. Chen, M. C. Lu, P. Y. Wang, Y. S. Lin and T. C. Wang* (November 14, 2015). "Design, synthesize and evaluate anticancer activity of ketone、methyloxime and amide containing anthraquinone derivatives", 2015 Annual Symposium of the Pharmaceutical Society of Taiwan, Tainan, Taiwan.

106. K. M. Chang, T. C. Wang, C. C. Kuo, I. L. Chen and C. C. Tzeng* (November 14, 2015). "Novel oxime-bearing coumarin derivatives act as potent Nrf2 ARE activators in vitro and in mouse model", 2015 Annual Symposium of the Pharmaceutical Society of Taiwan, Tainan, Taiwan.

107. K. M. Chang, Y. H. Lu, D. C. Wei, J. Y. Chen, S. H. Juang, I. L. Chen*, S. H. Juang * and T. C. Wang* (August 29-31, 2016). "Synthesis and Antiproliferative Evaluation of Oxime, Methyloxime, and Amide-containing Quinazoline Derivatives", 2016 PST Medicinal Chemistry Symposium, Kaoshiung, Taiwan.

108. I. L. Luoz, K. M. Chang, J. Y. Chen, D. C. Wei, I. L. Chen* and T. C. Wang* (December 17, 2016). "Design, synthesize and evaluate anticancer activity of ketone、methyloxime and amide containing anthraquinone derivatives", 2016 Annual Conference of the Pharmaceutical Society of Taiwan, Taipei, Taiwan.

109. K. M. Chang, L. C. Chen, S. H. Juang, D. C. Wei, T. C. Wang* and I. L. Chen* (June 26-28, 2017). “Design and synthesis serial novel naphthofuran derivatives as Nrf2 inhibitor”, 2017 TPST Medicinal Chemistry Symposium, Nantou, Taiwan.

 

 

Patents

  1. 發明人：曾誠齊, 陳義龍, 王泰吉, 鄧哲明,“抗血小板凝集活性之香豆衍生物”, 發明第5646164號, 美國專利, 1997/07/08.
  2. 發明人：陳日榮, 謝博銓, 郭文隆, 黃聰隆, 王泰吉, 郭代璜, 鍾靜宜, “厚朴萃取之新聯苯化合物及生物活性成分製備方法”, 發明第I515004號, 中華民國專利, 2016/01/01.
  3. 發明人：王泰吉, 張耿銘, “萘併呋喃衍生物及其製備方法與用於提升已產生抗藥性之癌細胞對化療藥物敏感性之應用”, 發明第I534139號, 中華民國專利, 2016/05/21.

 

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