Academic career

2005-

Assistant Professor, Department of Pharmacy, Tajen University 

1996-2005

Lecturer, Department of Food Science and Technology, Tajen University 

1984-1996

Assistant, Department of Food Science and Technology, Tajen University

Education

College

 Department of Pharmacy, China Medical College (1977-1982)

M. S.

Institute of Natural Herb, College of Kaohsiung Medicine (2003-2005)

Ph. D.

Graduate of Pharmacy, Kaohsiung Medical University (1999-2005)

Teaching Courses

Introduction of Traditional Chinese Medicine

Pentsa’ology

Chinese Pharmaceutics

Experiment of Chinese medicine formula

Research Area

Traditional Chinese Medicine

Chinese medicine formula

Recent Publications

Refereed journals

1. Jung San Chang, Kuo Chih Wang, Den En Shieh, Lien Chai Chiang. Liu-He-Tang inhibited plaque formation by human respiratory syncytial virus infection in cell lines of the human respiratory tract. Journal of Ethnopharmacology. 2011, 137, 1149-1155. ( SCI )
2. Jung San Changa,b, Kuo Chih Wangc, Den En Shieh, Fen Fang Hsue, Lien Chai Chiang. Ge-Gen-Tang has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of Ethnopharmacology. 2012, 139, 305-310. ( SCI )
3. Jung San Chang, Kuo Chih Wang, Chia Feng Yeh , Den En Shieh, Lien Chai Chiang. Fresh ginger ( Zingiber officinale ) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. Journal of Ethnopharmacology. 2013, 145, 146–151. ( SCI )
4. Chia Feng Yeh, Jung San Chang, Kuo Chih Wang, Den En Shieh, Lien Chai Chiang. Water extract of Cinnamomum cassia Blume inhibited human respiratory syncytial virus by preventing viral attachment, internalization and syncytium formation. Journal of Ethnopharmacology. 2013, 147, 321–326. ( SCI )
5. Jung San Chang, Chia Feng Yeh , Kuo Chih Wang , Den En Shieh, Ming Hong Yen, Lien Chai Chiang. Xiao-Qing-Long –Tang (Sho-seiryu-to) inhibited cytopathic effect of human respiratory syncytial virus in cell lines of human respiratory tract. Journal of Ethnopharmacology. 2013, 147, 481–487. ( SCI )
6. Ming-Hsien Huang, Chia-Tze Kao, Yi-Wen Chen, Tuan-Ti Hsu, Den-En Shieh, Tsui-Hsien Huang., Ming-You Shie. The synergistic effects of chinese herb and injectable calcium silicate/b-tricalcium phosphate composite on an osteogenic accelerator in vitro. Journal of Material Science. 2015, 26,161. ( SCI )
7. Nai-Jen Chang, Yi-Wen Chen, Den-En Shieh, Hsin-Yuan Fang and Ming-You Shie. The effects of injectable calcium silicate-based composites with the Chinese herb on an osteogenic accelerator in vitro. Biomedical Materials. 2015, 10. ( SCI )
8. Mei-Yin Chang, Den-En Shieh, Chung-Chi Chen, Ching-Sheng Yeh and Huei-Ping Dong. Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs. Int. J. Mol. Sci. 2015, 16, 28169–28179. ( SCI )

Conference Papers

1. Den-En Shieh¹, Guo-Hau Chiou¹ and Cheng-Dean Shih²*. Effect of aqueous extract of Rhodiola crenulata radix on blood lipid and blood coagulation in lard-treated rats. International Conference on Food Factors (ICOFF)，2011/11/20
2. Pei Jung, Lien; Yu Ren, Huang; Shu Tuan, Chiang; Man Yu, Chang; Den En, Shieh，Research on eye protection of supercritical fluid extract of Dunaliella salina compound ，2015 ISSF Symposium in Seoul，2015/10/11
3. Pei Jung, Lien; Pei Chi, Hsiao; Min Shih, Chen; Sing Ru, Cai; Den En, Shieh，The study on diabetic nephropathy of supercritical fluid extraction of agarwood，2015 ISSF Symposium in Seoul，2015/10/11
4. Den En, Shieh; Ru An, Cai; You Ru, Chen; Miao Yi, Wu; Guang Zhou Leu; Wei Ling Ho; and Pei Jung, Lien，The studies on the cosmetic function of natural product and essential oil 2017 ISSF Symposium in Japan Nagoya，2017/12/1