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蔡逸宏助理教授

蔡逸宏助理教授

蔡逸宏 助理教授

辦公室：達文西大樓U627

校內分機：2627

mailE-mail ：bear@tajen.edu.tw

cool現職

  • 大仁科技大學藥學系(含碩士班)，助理教授

smiley學歷

  • 高雄醫學大學，天然藥物研究所，藥學博士

indecision經歷

  • 大仁科技大學，藥學系，助理教授
  • 博士後研究員，高雄醫學大學天然藥物研究所，2016-2023
  • 移地研究交換學者，匈牙利賽德格大學藥學院生藥及藥化研究所，2019

cool專長領域

  • 植物新藥前端開發、天然物暨保健食品開發
  • 超臨界流體萃取、儀分光譜

enlightened成員

  • 中華天然藥物學會，永久會員，2023。
  • 中華天然藥物學會，學術小組成員，2023。

yes榮譽

  • 優秀天然藥物學術論文獎 – 年輕學者獎，第37屆天然藥物研討會暨李國雄院士紀念會-道法自然，2022。

surpriseJournal Papers

  1. Ya-Ting Chuang, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Fang-Rong Chang, Yi-Hong Tsai, Ching-Yu Yen, Hsueh-Wei Chang*, 2023. “Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products.” Cancers, 15(8), 2215.
  2. Yen Chi Loo, Hao-Chun Hu, Szu-YinYu, Yi-Hong Tsai, Michal Korinek, Yang-ChangWu*, Fang-Rong Chang*, Ying-JungChen*, 2023. “Development on potential skin anti-aging agents of Cosmos caudatus Kunth via inhibition of collagenase, MMP-1 and MMP-3 activities.” Phytomedicine, 110:154643.
  3. Wei-Yu Fang, Wan-Hsuan Chang, Yi-Hong Tsai, Hung-Te Hsu, Feng-Rong Chang, Chih-Lung Lin, Yi-Ching Lo*, 2023. “Water Extract of Guilu Erxian Jiao Improves Skeletal Muscle Mass and Function via Upregulation of Protein Synthesis, Glucose Homeostasis and Mitochondrial Biogenesis in in-vitro and in-vivo Studies.” J. Food Drug Anal., 31(1): 116–136.
  4. Wei-Yu Fang, Chih-Lung Lin, Wan-Hsuan Chang, Chih-Hsiang Chang, Yun-Cian Huang, Yi-Hong Tsai, Fang-Rong Chang, Yi-Ching Lo*, 2022. “Protective effects of a chalcone-based derivative AN07 on inflammation-associated myotube atrophy induced by lipopolysaccharide.” Int. J. Mol. Sci., 23(21):12929.
  5. Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai*, Fang-Rong Chang*, 2022. “Composition decipherment of F. pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference.” J. Food Drug Anal., 30(3), Article 9. 通訊作者論文。
  6. Wei-Kuang Lai, Yang-Chang Wu, Tai-Sheng Yeh, Chun-Ren Hsieh, Yi-Hong Tsai, Chien-Kei Wei, Chi-Ying Li, Ying-Chen Lu*, Fang-Rong Chang*, 2021. “The protoplast two-way fusions and fusant characteristics of Antrodia cinnamomea and Cordyceps militaris.” Food Sci. Hum. Wellness, 11(5), 1240-1251.
  7. Abdel Nasser B Singab, Nada M Mostafa, Yasmin A Elkhawas, Eman Al-Sayed, Mokhtar M Bishr, Ahmed M Elissawy, Mohamed S Elnaggar, Iten M Fawzy, Osama M Salama, Yi-Hong Tsai, Fang-Rong Chang*, 2021. “Cyclodepsipeptides: isolation from endophytic fungi of Sarcophyton ehrenbergi and verification of their larvicidal activity via in-vitro and in-silico studies.” Mar. Drugs., 20(5), 331.
  8. Yi-Hong Tsai, Fang-Rong Chang*, Yang Chang Wu*, 2022. “In memory of professor Kuo-Hsiung Lee (K. H. Lee).” J. Tradit. Complement. Med. 12(2), 217-218. 第一作者論文。
  9. Chi-Jung Tai, Mohamed El-Shazly, Yi-Hsin Yang, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang*, 2022. “The effectiveness of Fuzi in combination with routine heart failure treatment on chronic heart failure patients.” J. Ethnopharmacol., 289: 115040.
  10. Chiao-Chih Huang, Tzu-Ching Lin, Chiung-Hui Liu, Hao-Chun Hu, Szu-Yin Yu, Shu-Jing Wu, Ming-Hong Yen, Yi-Hong Tsai*, Fang-Rong Chang*, 2021. “Lipid metabolism and its mechanism triggered by supercritical CO2 extract of adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) bran in high fat diet-induced hyperlipidemic hamsters.” Front. Pharmacol., 12:785944. 通訊作者論文。
  11. Michal Korinek, Heba Handoussa, Yi-Hong Tsai, You-Ying Chen, Meng-Hua Chen, Zan-Wei Chiou, Yu Fang, Fang-Rong Chang, Chia-Hung Yen, Chung-Fan Hsieh, Bing-Hung Chen, Mohamed El-Shazly, Tsong-Long Hwang, 2021. “Anti-inflammatory and antimicrobial volatile oils: Fennel and cumin inhibit neutrophilic inflammation via regulating Calcium and MAPKs.” Front. Pharmacol., 12:674095.
  12. Kartiko Arif Purnomo, Michal Korinek, Yi-Hong Tsai, Hao-Chun Hu, Yi-Hsuan Wang, Anders Backlund, Tsong-Long Hwang, Bing-Hung Chen, Shih-Wei Wang, Chin-Chung Wu, Fang-Rong Chang*, 2021. “Decoding multiple biofunctions of maca on its anti-allergic, anti-inflammatory, anti-thrombotic, and pro-angiogenic activities.” J. Agri. Food Chem., 69(40):11856-11866.
  13. Bernard S. Canusa, Ivan L. Lawag, Oliver B. Villaflores, Vitthal D. Wagh, Michal Korinek, Yi-Hong Tsai, Fang-Rong Chang, Ma. Alicia M. Aguinaldo*, 2021. “α-Glucosidase inhibitors from the bark extract of ethno-antidiabetic Ceriops tagal (Perr.) C.B. Rob” Philipp. J. Sci., 151 (S1): 25-60.
  14. Yi-Hong Tsai1, Hao-Chun Hu1, Yu-Che Chuang, Kuei-Hung Lai, Yu-Ming Hsu, Tsong-Long Hwang, Chih-Chan Lin, Ferenc Fülöp, Yang-Chang Wu, Szu-Yin Yu, Yu-Ting Kuo*, Fang-Rong Chang*, 2021. “Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.” Nat. Prod. Res., 36(12):3043-3053. 第一作者論文。
  15. Ching-Chia Chang, Chi-Ying Li, Yi-Hong Tsai, Mohamed El-Shazly, Chien-Kei Wei, Zih-Jie Yang, Shu-Li Chen, Chin-Chung Wu, Yang-Chang Wu, Fang-Rong Chang *, 2021. “Bioactive polyketides from the pathogenic fungus of Epicoccum sorghinum.” Planta, 253(6):116.
  16. Chi-Jung Tai, Mohamed El-Shazly, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang*, 2021. “Uncovering modern clinical applications of Fuzi and Fuzi-based formulas: A nationwide descriptive study with market basket analysis.” Front. Pharmacol., 12:674095.
  17. Tzu-Jung Yu, Yuan-Bin Cheng, Li-Ching Lin, Yi-Hong Tsai, Bo-Yi Yao, Jen-Yang Tang, Fang-Rong Chang, Chia-Hung Yen, Fu Ou-Yang, Hsueh-Wei Chang*, 2021. “Physalis peruviana-derived physapruin A (PHA) inhibits breast cancer cell proliferation and induces oxidative-stress-mediated apoptosis and DNA damage.” Antioxidants, 10(3):393.
  18. Wei-Kuang Lai, Ying-Chen Lu, Chun-Ren Hsieh, Chien-Kei Wei, Yi-Hong Tsai, Fang-Rong Chang*, You Chan*, 2021. “Developing lactic acid bacteria as an oral healthy food.” Life-Basel, 11(4): 268.
  19. Hao-Chun Hu, Chi-Ying Li, Yi-Hong Tsai, Dai-Yun Yang, Yang-Chang Wu, Tsong-Long Hwang, Shu-Li Chen, Ferenc Fülöp, Attila Hunyadi, Chia-Hung Yen, Yuan-Bin Cheng, Fang-Rong Chang*, 2020. “Secondary metabolites and bioactivities of Aspergillus ochraceopetaliformis isolated from Anthurium brownie.” ACS Omega, 5(33):20991-20999.
  20. Chi-Ying Li, Ching-Chia Chang, Yi-Hong Tsai, Mohamed El-Shazly, Chin-Chung Wu, Shih-Wei Wang, Tsong-Long Hwang, Chien-Kei Wei, Judit Hohmann, Zih-Jie Yang, Yuan-Bin Cheng, Yang-Chang Wu, Fang-Rong Chang*, 2020. “Anti-inflammatory, antiplatelet aggregation, and antiangiogenesis polyketides from Epicoccum sorghinum: Toward an understating of its biological activities and potential applications.” ACS Omega, 5(19), 11092–11099.
  21. Chih-Wen Chen, Chih-Fong Tsai, Yi-Hong Tsai, Yang-Chang Wu*, Fang-Rong Chang*, 2020. “Association rule mining for the ordered placement of traditional Chinese medicine containers: An experimental study.” Medicine, 99(18): e20090.
  22. Chih‐Wen Chen, Yi‐Hong Tsai, Fang‐Rong Chang, Wei‐Chao, Lin*, 2020. “Ensemble feature selection in medical datasets: Combining filter, wrapper, and embedded feature selection results.” Expert Syst., e12553.
  23. Yun-Chien Lai, Chi-Jung Tai1, Mohamed El-Shazly, Yu-Che Chuang, Shu-Tuan Chiang, Yi-Hong Tsai, Dezső Csupor, Judith Hohmann, Yang-Chang Wu*, Fang-Rong Chang*, 2019. “Quantification and simplified detoxification investigation on Fuzi, root of Aconitum carmichaelii.” Nat. Prod. Commun., 14(10), 1-8.
  24. Yu-Ting Tseng, Yi-Hong Tsai¸ Ferenc Fülöp, Fang‐Rong Chang, and Yi-Ching Lo*, 2019. “2-Iodo-4’-methoxychalcone attenuates methylglyoxal-induced neurotoxicity by activation of GLP-1 receptor and enhancement of neurotrophic signal, antioxidant defense and glyoxalase pathway.” Molecules, 24(12), 2249.
  25. Hung Su, Kuan-Ting Liu, Bai-Hsiun Chen, Yen-Ping Lin, Yu-Min Jiang, Yi-Hong Tsai¸ Fang-Rong Chang, Jentaie Shiea*, Chi-Wei Lee*, 2019. “Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care.” J. Food Drug Anal., 27, 2, 415−427.
  26. Chi-Ting Hsieh, Fang-Rong Chang, Yi-Hong Tsai, Yang-Chang Wu and Tusty-Jiuan Hsieh*, 2018. “2-Bromo-4’-methoxychalcone and 2-iodo-4’-methoxychalcone prevent progression of hyperglycemia and obesity via 5’-adenosine-monophosphate-activated protein kinase in diet-induced obese mice.” Int. J. Mol. Sci., 19(9), 2763.
  27. Yi-Hong Tsai1, Chien-Kei Wei1, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh*, and Fang-Rong Chang*, 2017. “6-Paradol and 6-shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-paradol reduces blood glucose in high-fat diet mice.” Int. J. Mol. Sci., 18(1), 168. 第一作者論文。
  28. Michal Korinek, Yi-Hong Tsai, Mohamed El-Shazly, Kuei-Hung Lai, Anders Backlund, Shou-Fang Wu, Wan-Chun Lai, Tung-Ying Wu, Shu-Li Chen, Yang-Chang Wu, Yuan-Bin Cheng, Tsong-Long Hwang*, Bing-Hung Chen*, and Fang-Rong Chang*, 2017. “Anti-allergic hydroxy fatty acids from Typhonium blumei explored through ChemGPS-NP.” Front. Pharmacol., 8, 356.
  29. Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang-Rong Chang*, 2017. “Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa).” J. Food Drug Anal., 25(1), 187−196.
  30. Yi-Hong Tsai1, Yuan-Bin Cheng1, I-Wen Lo, Chen-Chang Haung, Yu-Chi Tsai, Ludger Beerhues, Mohamed El-Shazly, Ming-Feng Hou, Shyng-Shiou Yuan, Chin-Chung Wu, Fang-Rong Chang*, and Yang-Chang Wu*, 2015. “Pandalisines A and B, novel indolizidine alkaloids from the leaves of Pandanus utilis.” Bioorg. Med. Chem. Lett., 25, 4333–4336. 第一作者論文。
  31. Tung-Ying Wu, Ying-Chi Du, Yu-Ming Hsu, Chi-Yu Lu, Abdel Nasser B. Singab, Mohamed El-Shazly, Tsong-Long Hwang, Wan-Yu Lin, Kuei-Hung Lai, Mei-Chin Lu, Yi-Hong Tsai, Ming-Feng Hou, Tsai-Hui Du*, and Fang-Rong Chang*, 2013. “New approach to the characterization and quantification of Antrodia cinnamomea benzenoid components utilizing HPLC-PDA, qNMR and HPLC-tandem MS: Comparing the wild fruiting bodies and its artificial cultivated commercial products.” Food Res. Int., 51, 23−31.
  32. Yi-Hong Tsai1, Tusty-Jiuan Hsieh, Min-Chun Liao, Ying-Chi Du, Pei-Jung Lien, Chuan-Chia Sun, Fang-Rong Chang*, and Yang-Chang Wu*, 2012. “Anti-diabetic properties of non-polar Toona sinensis Roem. extract prepared by supercritical-CO2 fluid.” Food Chem. Toxicol., 50, 779−789. 第一作者論文。
  33. Chi-Ting Hsieh, Tusty-Jiuan Hsieh, Mohamed El-Shazly, Da-Wei Chuang, Yi-Hong Tsai, Chiao-Ting Yen, Shou-Fang Wu, Yang-Chang Wu*, and Fang-Rong Chang*, 2012. “Synthesis of Chalcone Derivatives as Potential Anti-diabetic Agents.” Bioorg. Med. Chem. Lett., 22, 3912−3915.
  34. Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Da-Wei Chuang, Yu-Ming Chung, Yi-Hong Tsai, Shou-Fang Wu, Michal Korinek, Ying-Chi Du, Chi-Ting Hsieh, Jeh-Jeng Wang*, and Fang-Rong Chang*, 2012. “Synthesis of carbamates by direct C–H bond activation of formamides.” Eur. J. Org. Chem., 34, 6760−6766.
  35. Tusty-Jiuan Hsieh, Pei-Chen Hsieh, Yi-Hong Tsai, Chia-Fang Wu, Chia-Chu Liu, Ming-Yen Lin, Ming-Tsang Wu*, 2012. “Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.” Toxicol. Sci., 130(1), 17-32.
  36. I-Min Liu, Wen-Jen Yu, Shorong-Shii Liou, Thing-Fong Tzeng, Yi-Hong Tsai, Juei-Tang Cheng*, 2006. “Role of alcohol in the induction of hepatic injury by chronic consumption of medicated wine.” J. Food Drug Anal., 15, 4, Article 4.

surprise專利

  • 發明-Extract of Toona sinensis from supercritical fluid extraction for treating diabetes and metabolic disease, the preparation method and the use thereof，美國，US10668122B2。

  • 發明-抗糖尿病及抗新陳代謝疾病之香椿超臨界萃取物、製備方法及用途，台灣，I492755。

  • 發明-抗糖尿病及抗新陈代谢疾病之香椿超临界萃取物、制备方法及用途，中國，CN102821771B。

  • 發明-Composition for treating diabetes and metabolic diseases and a preparation method thereof，美國，US9085520B2。

  • 發明-用於治療糖尿病及新陳代謝疾病的組合物及其製備方法，台灣，I417088。

  • 發明-Multiple beneficial functions of maca as anti-allergic, anti-neutrophilic inflammatory, anti-thrombotic, and pro-angiogenic agents and use thereof，美國，App. No. 63/195,150。

  • 發明-馬卡多種生物功能解碼 (マカ抽出物及びその用途)，日本，特願2022-088355。

enlightened技術轉移及授權

  • 抗糖尿病及抗新陳代謝疾病之香椿超臨界萃取物、製備方法及用途。中華民國專利I492755。
  • 抗糖尿病及抗新陳代謝疾病之香椿超臨界萃取物、製備方法及用途。中國專利CN102821771B。
  • Composition for treating diabetes and metabolic diseases and a preparation method thereof. 中華民國專利I417088, 美國專利US9085520B2。
  • 馬卡多種生物功能解碼。台灣、美國、日本、中國專利申請中。
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