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蔡逸宏助理教授

蔡逸宏助理教授

蔡逸宏 助理教授
113年度 藥學組2-3 班導師

辦公室：達文西大樓U627

校內分機：2627

E-mail: bear@tajen.edu.tw

cool整體學術績效與ORCID資訊

ORCID: https://orcid.org/0000-0003-4674-3363. 統計迄今 (2024/11/26止)，累積發表48篇學術論文。根據ORCID及Scopus preview資訊，論文總引用數927次於899篇SCI論文之中，h-index目前為15 (https://orcid.org/0000-0003-4674-3363、Scopus Author ID: 54944623200)。計有16則專利獲證或申請中，參與之研究技術轉移7件實際應用於產業。另參與過30件以上計劃之申請、統籌、執行與結案等，包含政府計畫及產學合作計畫。

angel現職

  • 大仁科技大學 藥學系(含碩士班)，助理教授
  • 大仁科技大學 秘書室-校務研究與永續發展辦公室，主任。

cool學歷

  • 高雄醫學大學，天然藥物研究所，藥學博士

smiley經歷

  • 大仁科技大學，藥學系，助理教授。
  • 博士後研究員，高雄醫學大學天然藥物研究所，2016-2023。
  • 移地研究交換學者，匈牙利賽德格大學藥學院生藥及藥化研究所，2019。

enlightened專長領域

  • 植物新藥前端開發、天然物暨保健食品開發。
  • 超臨界流體萃取、儀器分析、光譜學、藥物分析、生藥學。

wink學會成員

  • 中華天然藥物學會，永久會員。
  • 台灣藥學會，正式會員。
  • 中華天然藥物學會，學術小組成員，2024。
  • 中華天然藥物學會，學術小組成員，2023。

heart榮譽

  • 優秀天然藥物學術論文獎 – 年輕學者獎，第37屆天然藥物研討會暨李國雄院士紀念會-道法自然，2022。

enlightened期刊審查

  1. Review Editor for Ethnopharmacology, Frontiers in Pharmacology (Impact factor = 4.40. Ranked Q1, Top 18.2% in PHARMACOLOGY & PHARMACY - SCIE).
  2. Reviewer, Phytomedicine. (Impact factor = 6.70. Ranked Q1, Top 3.5% in INTEGRATIVE & COMPLEMENTARY MEDICINE - SCIE).

cool學術期刊文章發表

  1. Ya-Ting Chuang, Ching-Yu Yen, Jen-Yang Tang, Fang-Rong Chang, Yi-Hong Tsai, Kuo-Chuan Wu, Tsu-Ming Chien, Hsueh-Wei Chang, 2024. “The modulation of immune cell death in connection to microRNAs and natural products.” Front. Immunol., accepted, in press. (Impact factor = 5.7. Ranked Q1, Top 20.2% in IMMUNOLOGY - SCIE).
  2. Ya-Ting Chuang, Ching-Yu Yen, Tsu-Ming Chien, Fang-Rong Chang, Kuo-Chuan Wu, Yi-Hong Tsai, Jun-Ping Shiau, Hsueh-Wei Chang, 2024. “Natural products modulate phthalate-associated miRNAs and targets.” Ecotoxicol. Environ. Saf., 284:117015. (Impact factor = 6.2. Ranked Q1, Top 8.0% in TOXICOLOGY - SCIE).
  3. Ya-Ting Chuang, Ching-Yu Yen, Jen-Yang Tang, Kuo-Chuan Wu, Fang-Rong Chang, Yi-Hong Tsai, Tsu-Ming Chien, Hsueh-Wei Chang, 2024. “Marine anticancer drugs in modulating miRNAs and antioxidant signaling.” Chem. Biol. Interact., 25(399):111142. (Impact factor = 4.7. Ranked Q1, Top 15.4% in PHARMACOLOGY & PHARMACY - SCIE).
  4. Ya-Ting Chuang, Ching-Yu Yen, Tsu-Ming Chien, Fang-Rong Chang, Yi-Hong Tsai, Kuo-Chuan Wu, Jen-Yang Tang, Hsueh-Wei Chang, 2024. “Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis.” Int. J. Mol. Sci., 25(11): 6083. (Impact factor = 4.9. Ranked Q1, Top 20.9% in BIOCHEMISTRY & MOLECULAR BIOLOGY - SCIE).
  5. Hao-Chun Hu, Szu-Yin Yu, Yi-Hong Tsai, Pei-Wen Hsieh, Hui-Chun Wang, Yan-Ning Chen, Ya-Ting Chuang, Min-Yu Lee, Hsueh-Wei Chang, Hao-Chun Hu, Yang-Chang Wu, Fang-Rong Chang, István Szatmári, Ferenc Fülöp, 2024. “Synthesis of bioactive evodiamine and rutaecarpine analogues under a ball milling condition.” Org. Biomol. Chem., 22, 2620-2629. (Impact factor = 2.9. Ranked Q1, Top 21.6% in CHEMISTRY, ORGANIC - SCIE).
  6. Yi-Hong Tsai1, Yen Chi Loo1, Hsieh Chen, Hui-Ping Hsieh, Yen-Chang Chen, Hsueh-Er Chen, Zhi-Hu Lin, Tse-Hung Huang, I-Min Liu, Chia-Ching Liaw, Fang-Rong Chang, 2024. “Quality and production enhancement of fish mint, Houttuynia cordata Thunb., cultivated in a hydroponic planting system with designed plant growth-promoting additives.” Heliyon, 10(7):e28755. (Impact factor = 3.4. Ranked Q1, Top 20.5% in MULTIDISCIPLINARY SCIENCES - SCIE). 第一作者論文.
  7. Ya-Ting Chuang, Ching-Yu Yen, Jen-Yang Tang, Fang-Rong Chang, Yi-Hong Tsai, Kuo-Chuan Wu, Tsu-Ming Chien, Hsueh-Wei Chang, 2024. “Protein phosphatase 2A modulation and connection with miRNAs and natural products.” Environ. Toxicol, 39(6):3612-3627. (Impact factor = 4.4. Ranked Q1 in TOXICOLOGY - SCIE).
  8. Ya-Ting Chuang, Ching-Yu Yen, Jun-Ping Shiau, Fang-Rong Chang, Chang-Yih Duh, Ping-Jyun Sung, Kuan-Liang Chen, Yi-Hong Tsai, Jen-Yang Tang, Jiiang-Huei Jeng, Jyh-Horng Sheu, Hsueh-Wei Chang, 2024. “Demethoxymurrapanine, an indole-naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells.” Environ. Toxicol., 39(3), 1221–1234. (Impact factor = 4.4. Ranked Q1, Top 18% in TOXICOLOGY - SCIE).
  9. Jen-Yang Tang, Ya-Ting Chuang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Yi-Hong Tsai, Ammad Ahmad Farooqi, Hsueh-Wei Chang, 2023. “Connection between Radiation-Regulating Functions of Natural Products and miRNAs Targeting Radiomodulation and Exosome Biogenesis.” Int. J. Mol. Sci., 24(15):12449. (Impact factor = 6.208. Ranked Q1, Top 23% in BIOCHEMISTRY & MOLECULAR BIOLOGY - SCIE).
  10. Ya-Ting Chuang, Jun-Ping Shiau, Jen-Yang Tang, Ammad Ahmad Farooqi, Fang-Rong Chang, Yi-Hong Tsai, Ching-Yu Yen, Hsueh-Wei Chang*, 2023. “Connection of Cancer Exosomal LncRNAs, Sponging miRNAs, and Exosomal Processing and Their Potential Modulation by Natural Products.” Cancers, 15(8), 2215. (Impact factor = 6.675. Ranked Q1, Top 24.29% in ONCOLOGY - SCIE).
  11. Yen Chi Loo, Hao-Chun Hu, Szu-YinYu, Yi-Hong Tsai, Michal Korinek, Yang-ChangWu*, Fang-Rong Chang*, Ying-JungChen*, 2023. “Development on potential skin anti-aging agents of Cosmos caudatus Kunth via inhibition of collagenase, MMP-1 and MMP-3 activities.” Phytomedicine, 110:154643.  (Impact factor = 6.655. Ranked Q1, No.1 in INTEGRATIVE & COMPLEMENTARY MEDICINE - SCIE).
  12. Wei-Yu Fang, Wan-Hsuan Chang, Yi-Hong Tsai, Hung-Te Hsu, Fang-Rong Chang, Chih-Lung Lin, Yi-Ching Lo*, 2023. “Guilu Erxian Jiao enhances protein synthesis, glucose homeostasis, mitochondrial biogenesis and slow-twitch fibers in the skeletal muscle.” J. Food Drug Anal., 31(1), Article 8. (Impact factor = 6.157. Ranked Q1, Top 16% in PHARMACOLOGY & PHARMACY - SCIE).
  13. Wei-Yu Fang, Chih-Lung Lin, Wan-Hsuan Chang, Chih-Hsiang Chang, Yun-Cian Huang, Yi-Hong Tsai, Fang-Rong Chang, Yi-Ching Lo*, 2022. “Protective effects of a chalcone-based derivative AN07 on inflammation-associated myotube atrophy induced by lipopolysaccharide.” Int. J. Mol. Sci., 23(21):12929. (Impact factor = 6.208. Ranked Q1, Top 23% in BIOCHEMISTRY & MOLECULAR BIOLOGY - SCIE).
  14. Hao-Chun Hu, Szu-Yin Yu, Xiao-Shan Hung, Chun-Han Su, Yu-Liang Yang, Chien-Kei Wei, Yuan-Bin Cheng, Yang-Chang Wu, Chia-Hung Yen, Tsong-Long Hwang, Shu-Li Chen, István Szatmári, Attila Hunyadi, Yi-Hong Tsai*, Fang-Rong Chang*, 2022. “Composition decipherment of F. pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference.” J. Food Drug Anal., 30(3), Article 9. (Impact factor = 6.157. Ranked Q1, Top 16% in PHARMACOLOGY & PHARMACY - SCIE). 通訊作者論文。
  15. Wei-Kuang Lai, Yang-Chang Wu, Tai-Sheng Yeh, Chun-Ren Hsieh, Yi-Hong Tsai, Chien-Kei Wei, Chi-Ying Li, Ying-Chen Lu*, Fang-Rong Chang*, 2021. “The protoplast two-way fusions and fusant characteristics of Antrodia cinnamomea and Cordyceps militaris.” Food Sci. Hum. Wellness, 11(5), 1240-1251. (Impact factor = 8.022. Ranked Q1, Top 10% in NUTRITION & DIETETICS - SCIE).
  16. Michal Korinek, Heba Handoussa, Olha Mykhailenko, Meng-Hua Chen, Zan-Wei Chiou, You-Ying Chen, Yi-Hong Tsai, Bing-Hung Chen, Mohamed El-Shazly, Tsong-Long Hwang*, 2021. “Antimicrobial and anti-inflammatory effects of volatile oils widely used in Mediterranean diet.” Free Radic. Biol. Med., 165(1), 38.
  17. Abdel Nasser B Singab, Nada M Mostafa, Yasmin A Elkhawas, Eman Al-Sayed, Mokhtar M Bishr, Ahmed M Elissawy, Mohamed S Elnaggar, Iten M Fawzy, Osama M Salama, Yi-Hong Tsai, Fang-Rong Chang*, 2021. “Cyclodepsipeptides: isolation from endophytic fungi of Sarcophyton ehrenbergi and verification of their larvicidal activity via in-vitro and in-silico studies.” Mar. Drugs., 20(5), 331. (Impact factor = 6.085, ranked Q1, Top 16% in CHEMISTRY, MEDICINAL - SCIE).
  18. Yi-Hong Tsai, Fang-Rong Chang*, Yang Chang Wu*, 2022. “In memory of professor Kuo-Hsiung Lee (K. H. Lee).” J. Tradit. Complement. Med. 12(2), 217-218. (Impact factor = 4.221. Ranked Q2, top 27% in INTEGRATIVE & COMPLEMENTARY MEDICINE)). 第一作者論文。
  19. Chi-Jung Tai, Mohamed El-Shazly, Yi-Hsin Yang, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang*, 2022. “The effectiveness of Fuzi in combination with routine heart failure treatment on chronic heart failure patients.” J. Ethnopharmacol., 289: 115040. (Impact factor = 5.195. Ranked Q1, Top 12.98% in INTEGRATIVE & COMPLEMENTARY MEDICINE - SCIE).
  20. Chiao-Chih Huang, Tzu-Ching Lin, Chiung-Hui Liu, Hao-Chun Hu, Szu-Yin Yu, Shu-Jing Wu, Ming-Hong Yen, Yi-Hong Tsai*, Fang-Rong Chang*, 2021. “Lipid metabolism and its mechanism triggered by supercritical CO2 extract of adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) bran in high fat diet-induced hyperlipidemic hamsters.” Front. Pharmacol., 12:785944. (Impact factor = 5.988. Ranked Q1, Top 18% in PHARMACOLOGY & PHARMACY - SCIE). 通訊作者論文。
  21. Michal Korinek, Heba Handoussa, Yi-Hong Tsai, You-Ying Chen, Meng-Hua Chen, Zan-Wei Chiou, Yu Fang, Fang-Rong Chang, Chia-Hung Yen, Chung-Fan Hsieh, Bing-Hung Chen, Mohamed El-Shazly, Tsong-Long Hwang, 2021. “Anti-inflammatory and antimicrobial volatile oils: Fennel and cumin inhibit neutrophilic inflammation via regulating Calcium and MAPKs.” Front. Pharmacol., 12:674095. (Impact factor = 5.988. Ranked Q1, Top 18 in PHARMACOLOGY & PHARMACY - SCIE).
  22. Kartiko Arif Purnomo, Michal Korinek, Yi-Hong Tsai, Hao-Chun Hu, Yi-Hsuan Wang, Anders Backlund, Tsong-Long Hwang, Bing-Hung Chen, Shih-Wei Wang, Chin-Chung Wu, Fang-Rong Chang*, 2021. “Decoding multiple biofunctions of maca on its anti-allergic, anti-inflammatory, anti-thrombotic, and pro-angiogenic activities.” J. Agri. Food Chem., 69(40):11856-11866. (Impact factor = 5.895. Ranked Q1, Top 10% in AGRICULTURE, MULTIDISCIPLINARY - SCIE).
  23. Bernard S. Canusa, Ivan L. Lawag, Oliver B. Villaflores, Vitthal D. Wagh, Michal Korinek, Yi-Hong Tsai, Fang-Rong Chang, Ma. Alicia M. Aguinaldo*, 2021. “α-Glucosidase inhibitors from the bark extract of ethno-antidiabetic Ceriops tagal (Perr.) C.B. Rob” Philipp. J. Sci., 151 (S1): 25-60.
  24. Yi-Hong Tsai1, Hao-Chun Hu1, Yu-Che Chuang, Kuei-Hung Lai, Yu-Ming Hsu, Tsong-Long Hwang, Chih-Chan Lin, Ferenc Fülöp, Yang-Chang Wu, Szu-Yin Yu, Yu-Ting Kuo*, Fang-Rong Chang*, 2021. “Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.” Nat. Prod. Res., 36(12):3043-3053. (Impact factor = 2.861. Ranked Q2 in CHEMISTRY, APPLIED - SCIE). 第一作者論文。
  25. Ching-Chia Chang, Chi-Ying Li, Yi-Hong Tsai, Mohamed El-Shazly, Chien-Kei Wei, Zih-Jie Yang, Shu-Li Chen, Chin-Chung Wu, Yang-Chang Wu, Fang-Rong Chang *, 2021. “Bioactive polyketides from the pathogenic fungus of Epicoccum sorghinum.” Planta, 253(6):116. (Impact factor = 4.540. Ranked Q1, Top 17% in PLANT SCIENCES - SCIE).
  26. Chi-Jung Tai, Mohamed El-Shazly, Yi-Hong Tsai, Dezső Csupor, Judit Hohmann, Yang-Chang Wu, Tzyy-Guey Tseng, Fang-Rong Chang*, Hui-Chun Wang*, 2021. “Uncovering modern clinical applications of Fuzi and Fuzi-based formulas: A nationwide descriptive study with market basket analysis.” Front. Pharmacol., 12:674095. (Impact factor = 5.988. Ranked Q1, Top 18 in PHARMACOLOGY & PHARMACY - SCIE).
  27. Tzu-Jung Yu, Yuan-Bin Cheng, Li-Ching Lin, Yi-Hong Tsai, Bo-Yi Yao, Jen-Yang Tang, Fang-Rong Chang, Chia-Hung Yen, Fu Ou-Yang, Hsueh-Wei Chang*, 2021. “Physalis peruviana-derived physapruin A (PHA) inhibits breast cancer cell proliferation and induces oxidative-stress-mediated apoptosis and DNA damage.” Antioxidants, 10(3):393. (Impact factor = 7.675. Ranked Q1, Top 6% in CHEMISTRY, MEDICINAL - SCIE).
  28. Wei-Kuang Lai, Ying-Chen Lu, Chun-Ren Hsieh, Chien-Kei Wei, Yi-Hong Tsai, Fang-Rong Chang*, You Chan*, 2021. “Developing lactic acid bacteria as an oral healthy food.” Life-Basel, 11(4): 268. (Impact factor = 3.251. Ranked Q2 in BIOLOGY - SCIE).
  29. Hao-Chun Hu, Chi-Ying Li, Yi-Hong Tsai, Dai-Yun Yang, Yang-Chang Wu, Tsong-Long Hwang, Shu-Li Chen, Ferenc Fülöp, Attila Hunyadi, Chia-Hung Yen, Yuan-Bin Cheng, Fang-Rong Chang*, 2020. “Secondary metabolites and bioactivities of Aspergillus ochraceopetaliformis isolated from Anthurium brownie.” ACS Omega, 5(33):20991-20999. (Impact factor = 4.132. Ranked Q2 in CHEMISTRY, MULTIDISCIPLINARY - SCIE).
  30. Chi-Ying Li, Ching-Chia Chang, Yi-Hong Tsai, Mohamed El-Shazly, Chin-Chung Wu, Shih-Wei Wang, Tsong-Long Hwang, Chien-Kei Wei, Judit Hohmann, Zih-Jie Yang, Yuan-Bin Cheng, Yang-Chang Wu, Fang-Rong Chang*, 2020. “Anti-inflammatory, antiplatelet aggregation, and antiangiogenesis polyketides from Epicoccum sorghinum: Toward an understating of its biological activities and potential applications.” ACS Omega, 5(19), 11092–11099. (Impact factor = 4.132. Ranked Q2 in CHEMISTRY, MULTIDISCIPLINARY - SCIE).
  31. Chih-Wen Chen, Chih-Fong Tsai, Yi-Hong Tsai, Yang-Chang Wu*, Fang-Rong Chang*, 2020. “Association rule mining for the ordered placement of traditional Chinese medicine containers: An experimental study.” Medicine, 99(18): e20090. (Impact factor = 1.817. Ranked Q3 in MEDICINE, GENERAL & INTERNAL – SCIE).
  32. Chih‐Wen Chen, Yi‐Hong Tsai, Fang‐Rong Chang, Wei‐Chao, Lin*, 2020. “Ensemble feature selection in medical datasets: Combining filter, wrapper, and embedded feature selection results.” Expert Syst., e12553. (Impact factor = 2.812. Ranked Q2, Top 34% in COMPUTER SCIENCE, THEORY & METHODS - SCIE).
  33. Yun-Chien Lai, Chi-Jung Tai1, Mohamed El-Shazly, Yu-Che Chuang, Shu-Tuan Chiang, Yi-Hong Tsai, Dezső Csupor, Judith Hohmann, Yang-Chang Wu*, Fang-Rong Chang*, 2019. “Quantification and simplified detoxification investigation on Fuzi, root of Aconitum carmichaelii.” Nat. Prod. Commun., 14(10), 1-8.
  34. Yu-Ting Tseng, Yi-Hong Tsai¸ Ferenc Fülöp, Fang‐Rong Chang, and Yi-Ching Lo*, 2019. “2-Iodo-4’-methoxychalcone attenuates methylglyoxal-induced neurotoxicity by activation of GLP-1 receptor and enhancement of neurotrophic signal, antioxidant defense and glyoxalase pathway.” Molecules, 24(12), 2249.
  35. Hung Su, Kuan-Ting Liu, Bai-Hsiun Chen, Yen-Ping Lin, Yu-Min Jiang, Yi-Hong Tsai¸ Fang-Rong Chang, Jentaie Shiea*, Chi-Wei Lee*, 2019. “Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care.” J. Food Drug Anal., 27, 2, 415−427.
  36. Chi-Ying Li, I-Wen Lo, Yen-Ping Hsueh, Yu-Ming Chung, Shih-Wei Wang, Michal Korinek, Yi-Hong Tsai¸ Yuan-Bin Cheng, Tsong-Long Hwang, Clay C. C. Wang, Fang-Rong Chang, Yang-Chang Wu, 2019. “Epigenetic manipulation induces the production of coumarin-type secondary metabolite from Arthrobotrys foliicola.” Isr. J. Chem., 59(5), 432-438.
  37. Chi-Ting Hsieh, Fang-Rong Chang, Yi-Hong Tsai, Yang-Chang Wu and Tusty-Jiuan Hsieh*, 2018. “2-Bromo-4’-methoxychalcone and 2-iodo-4’-methoxychalcone prevent progression of hyperglycemia and obesity via 5’-adenosine-monophosphate-activated protein kinase in diet-induced obese mice.” Int. J. Mol. Sci., 19(9), 2763.
  38. Yi-Hong Tsai1, Chien-Kei Wei1, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh*, and Fang-Rong Chang*, 2017. “6-Paradol and 6-shogaol, the pungent compounds of ginger, promote glucose utilization in adipocytes and myotubes, and 6-paradol reduces blood glucose in high-fat diet mice.” Int. J. Mol. Sci., 18(1), 168. 第一作者論文。
  39. Michal Korinek, Yi-Hong Tsai, Mohamed El-Shazly, Kuei-Hung Lai, Anders Backlund, Shou-Fang Wu, Wan-Chun Lai, Tung-Ying Wu, Shu-Li Chen, Yang-Chang Wu, Yuan-Bin Cheng, Tsong-Long Hwang*, Bing-Hung Chen*, and Fang-Rong Chang*, 2017. “Anti-allergic hydroxy fatty acids from Typhonium blumei explored through ChemGPS-NP.” Front. Pharmacol., 8, 356.
  40. Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang-Rong Chang*, 2017. “Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa).” J. Food Drug Anal., 25(1), 187−196.
  41. Santhaseelan Henciya, Prabha Seturaman, Arthur Rathinam James, Yi-Hong Tsai, Rahul Nikam, Yang-Chang Wu, Hans-Uwe Dahms, Fang-Rong Chang*, 2017. “Corrigendum to “Biopharmaceutical potentials of Prosopis spp. (Mimosaceae, Leguminosa)” (Journal of Food and Drug Analysis (2017) 25(1) (S1021949816301697) (10.1016/j.jfda.2016.11.001))” J. Food Drug Anal., 25(3), 748−749.
  42. Yi-Hong Tsai1, Yuan-Bin Cheng1, I-Wen Lo, Chen-Chang Haung, Yu-Chi Tsai, Ludger Beerhues, Mohamed El-Shazly, Ming-Feng Hou, Shyng-Shiou Yuan, Chin-Chung Wu, Fang-Rong Chang*, and Yang-Chang Wu*, 2015. “Pandalisines A and B, novel indolizidine alkaloids from the leaves of Pandanus utilis.” Bioorg. Med. Chem. Lett., 25, 4333–4336. 第一作者論文。
  43. Tung-Ying Wu, Ying-Chi Du, Yu-Ming Hsu, Chi-Yu Lu, Abdel Nasser B. Singab, Mohamed El-Shazly, Tsong-Long Hwang, Wan-Yu Lin, Kuei-Hung Lai, Mei-Chin Lu, Yi-Hong Tsai, Ming-Feng Hou, Tsai-Hui Du*, and Fang-Rong Chang*, 2013. “New approach to the characterization and quantification of Antrodia cinnamomea benzenoid components utilizing HPLC-PDA, qNMR and HPLC-tandem MS: Comparing the wild fruiting bodies and its artificial cultivated commercial products.” Food Res. Int., 51, 23−31.
  44. Chia-Lin Lee, Tsong-Long Hwang, Wan-Jung He, Yi-Hong Tsai, Chiao-Ting Yen, Hsin-Fu Yen, Chao-Jung Chen, Wei-Yi Chang, Yang-Chang Wu, 2013. “Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum.” Phytochemistry, 95, 315-321.
  45. Yi-Hong Tsai1, Tusty-Jiuan Hsieh, Min-Chun Liao, Ying-Chi Du, Pei-Jung Lien, Chuan-Chia Sun, Fang-Rong Chang*, and Yang-Chang Wu*, 2012. “Anti-diabetic properties of non-polar Toona sinensis Roem. extract prepared by supercritical-CO2 fluid.” Food Chem. Toxicol., 50, 779−789. 第一作者論文。
  46. Chi-Ting Hsieh, Tusty-Jiuan Hsieh, Mohamed El-Shazly, Da-Wei Chuang, Yi-Hong Tsai, Chiao-Ting Yen, Shou-Fang Wu, Yang-Chang Wu*, and Fang-Rong Chang*, 2012. “Synthesis of Chalcone Derivatives as Potential Anti-diabetic Agents.” Bioorg. Med. Chem. Lett., 22, 3912−3915.
  47. Balaji D. Barve, Yang-Chang Wu, Mohamed El-Shazly, Da-Wei Chuang, Yu-Ming Chung, Yi-Hong Tsai, Shou-Fang Wu, Michal Korinek, Ying-Chi Du, Chi-Ting Hsieh, Jeh-Jeng Wang*, and Fang-Rong Chang*, 2012. “Synthesis of carbamates by direct C–H bond activation of formamides.” Eur. J. Org. Chem., 34, 6760−6766.
  48. Tusty-Jiuan Hsieh, Pei-Chen Hsieh, Yi-Hong Tsai, Chia-Fang Wu, Chia-Chu Liu, Ming-Yen Lin, Ming-Tsang Wu*, 2012. “Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.” Toxicol. Sci., 130(1), 17-32.
  49. I-Min Liu, Wen-Jen Yu, Shorong-Shii Liou, Thing-Fong Tzeng, Yi-Hong Tsai, Juei-Tang Cheng*, 2006. “Role of alcohol in the induction of hepatic injury by chronic consumption of medicated wine.” J. Food Drug Anal., 15, 4, Article 4.

enlightened專利

  1. 發明-Extract of Toona sinensis from supercritical fluid extraction for treating diabetes and metabolic disease, the preparation method and the use thereof ，美國，US10668122B2。
  2. 發明-抗糖尿病及抗新陳代謝疾病之香椿超臨界萃取物、製備方法及用途，台灣，I492755。
  3. 發明-抗糖尿病及抗新陈代谢疾病之香椿超临界萃取物、制备方法及用途，中國，ZL201080060000.0。
  4. 發明-Composition for treating diabetes and metabolic diseases and a preparation method thereof，美國，US9085520B2。
  5. 發明-用於治療糖尿病及新陳代謝疾病的組合物及其製備方法，台灣，I417088。
  6. 發明-Multiple beneficial functions of maca as anti-allergic, anti-neutrophilic inflammatory, anti-thrombotic, and pro-angiogenic agents and use thereof，美國，US 11,771,729 B2。
  7. 發明-馬卡多種生物功能解碼 (マカ抽出物及びその用途) ，日本，JP7446003B2。
  8. 發明-馬卡多種生物功能解碼，中國，CN 115477604 B。
  9. 發明-馬卡多種生物功能解碼，台灣，公開號：202300165。
  10. 發明-可抗氧化、抗發炎、抗UVB、抗過敏、美白、或抗皺的洛神葵種子萃取物，台灣，TW202337482A。
  11. 發明-可抗氧化、抗发炎、抗UVB、抗过敏、美白、保湿、以及抗皱的洛神葵种子萃取物，中國，公開號：CN116019744A。
  12. 發明-Antioxidant, anti-inflammatory, anti-uvb, anti-allergic, whitening, and anti-wrinkle roselle seed extract，美國， Filing。
  13. 發明-海葡萄萃取物用於製備促進皮膚抗發炎、抗氧化及抗癌組合物之用途，台灣，I790760。
  14. 發明-海葡萄組合物用於促進皮膚抗發炎、抗氧化、減緩膠原蛋白降解流失及抗癌之用途，台灣，I837515。
  15. 發明-魚腥草水耕培養液、系統及生產之魚腥草的萃取物與製備，台灣，I838761。
  16. 新型-萃取愛玉枝條與愛玉葉之裝置，台灣，M643653。

angel技術轉移及授權

  1. 抗糖尿病及抗新陳代謝疾病之香椿超臨界萃取物、製備方法及用途。中華民國專利I492755。專利權人：高雄醫學大學。技轉公司：慧宇應用生物科技有限公司，團隊技轉金300,000 NTD。
  2. 抗糖尿病及抗新陳代謝疾病之香椿超臨界萃取物、製備方法及用途。中國專利CN102821771B。專利權人：高雄醫學大學。技轉公司：慧宇應用生物科技有限公司，團隊技轉金額1200,000 NTD。
  3. Composition for treating diabetes and metabolic diseases and a preparation method thereof. 中華民國專利I417088, 美國專利US9085520B2。專利權人：高雄醫學大學。技轉公司：合一生技股份有限公司，合約金額30,000,000 (in milestone)。
  4. 馬卡多種生物功能解碼。美國專利US 11771729 B2、日本專利JP7446003B2、台灣、中國專利申請中。專利權人：高雄醫學大學。技轉公司：鈞禾生物科技股份有限公司。技轉金額：2,000,000。
  5. 鋅甘飲。專利權人：高雄醫學大學。技轉公司：喬本生醫股份有限公司。技轉金額：1,000,000。
  6. 活力亞補芝麻素牛樟飲。專利權人：高雄醫學大學。技轉公司：喬本生醫股份有限公司。技轉金額：1,000,000。
  7. 能量美體素。專利權人：高雄醫學大學。技轉公司：喬本生醫股份有限公司。技轉金額：1,000,000。

cool計畫參與及執行

  1. 政府計劃
  1. 國科會(科技部)計畫－整合型：
  • 預防心血管風險及代謝症候群之精準農業保健產品開發- (111-2321-B-037 -004)，2022/07/01 ~ 2025/06/30。
  1. 國科會(科技部)計畫－一般型：
  • (計畫主持人) NSTC-113-2320-B-127 -001，2024/08/01 ~ 2025/07/31。
  • 透過化學性與物理性刺激基因調控開發真菌二次代謝物 (111-2320-B-037 -020 -MY3)，2022/08/01 ~ 2025/07/31。
  • 透過化學性與物理性刺激基因調控開發真菌二次代謝物 (111-2320-B-037 -020 -MY3)，2022/08/01 ~ 2025/07/31。
  • 真菌遺傳與訊息表達調控於天然產物之研發 (MOST 108-2320-B-037-022-MY3) +真菌遺傳調控產天然物之結構活性相關性探討暨醫藥用天然物之創新研發 (自由型擴充加值Add-on國際合作研究計畫)，2019/08/01 ~ 2022/07/31。
  • 表觀遺傳調控方法應用於真菌功能性物質開發 II (MOST 105-2628-B-037-001-MY3) + 經表觀遺傳技術調控之真菌功能性二次代謝物的半合成或全合成策略 (自由型擴充加值Add-on國際合作研究計畫)，2016/08/01~2019/10/31。
  • 沉香抗過敏物質之研發 (MOST 106-2320-B-037-008-MY2)，2017/08/01~2019/07/31。
  • 表觀遺傳調控方法應用於真菌功能性物質開發 (MOST 102-2628-B-037 -003-MY3)，2013/08/01 ~ 2016/07/31。
  1. 國科會(科技部)計畫－跨國交流型：
  • 找尋生物活性化合物之化學策略IV. (2/2) - 台匈 HAS-MOST雙邊研究/人員交流PPP計畫 (MOST 111-2927-I-037-501)，2022/01/01 ~ 2022/12/31。
  • 找尋生物活性化合物之化學策略IV. (1/2) - 台匈 HAS-MOST雙邊研究/人員交流PPP計畫 (MOST 109-2927-I-037-502)，2020/11/01 ~ 2021/10/30。
  • 找尋生物活性化合物之化學策略III. (2/2) - 台匈 (MOST-HAS) 雙邊計畫人員交流PPP計畫 (MOST 107-2911-I-037-502)，2018/05/01~2019/10/31。
  • 找尋生物活性化合物之化學策略III. (1/2) - 台匈 (MOST-HAS) 雙邊計畫人員交流PPP計畫 (MOST 106-2911-I-037-504)，2017/01/01~2017/12/31。
  • 找尋生物活性化合物之化學策略II. (2/2) - 台匈 (MOST-HAS) 雙邊計畫人員交流PPP計畫 (MOST 105-2911-I-037-501)，2016/01/01~2016/12/31。
  1. 國科會(科技部)計畫－國家型：
  • 新型查耳酮衍生物對抗糖尿病與代謝調節異常新藥之開發(II)，MOST 99-2323-B-037-002，2010/10/01 ~ 2011/07/31。
  • WYC-01 與WYC-02 新藥前臨床開發研究，MOST 99-2323-B-039 -002，2010/08/01 ~ 2011/07/31。
  • 新型查耳酮衍生物對抗糖尿病與代謝調節異常新藥之開發，MOST 98-2323-B-037 -004，2009/10/01 ~ 2010/10/31。
  1. 行政院農業委員會農糧署：
  • 106年「建立菲律賓熱帶設施基地及保健作物產品合作開發」，106農科-21.1.3-糧-Z2，2017/01/01 ~ 2017/12/31 (新南向)。
  • 107年「建立菲律賓熱帶設施基地及保健作物產品合作開發」，107農科-17.1.3-糧-Z1，2018/01/01 ~ 2018/12/31 (新南向)。
  1. 經濟部及地方型小型企業創新研發計畫 (SBIR)，協助傳統產業技術開發計畫 (CITD)
  • 高值化植萃天然物之魚腥草智慧栽種與應用開發聯盟計畫，慧穎應用生物科技有限公司，2021/07/01 ~ 2022/06/30。
  • 洛神子油於抗過敏鎮膚保養原料及產品之開發，慧穎應用生物科技有限公司，2020/09/01 ~ 2021/07/31。
  • 沉香子油於抗過敏及抗光老化原料及產品之開發計畫，慧穎應用生物科技有限公司，2017/07/12 ~ 2018/07/11。
  • 台灣本土天然綠色製程萃取物-抗代謝症候群超臨界香椿萃取物產品研發計畫，慧穎應用生物科技有限公司，2012/10/01 ~ 2013/06/30。
  • 南國小薊肌膚保養品與降血糖產品開發，洸鼎生物科技有限公司，2012/07/01 ~ 2012/12/31。
  1. 經濟部財團法人金屬工業研究發展中心
  • 土肉桂及香椿萃取物對於改善新陳代謝症候群之效用評估及機轉探討，2010/06/15 ~ 2010/11/30。
  • 土肉桂及香椿萃取物對於改善細胞胰島素抗阻性之效用評估，2008/09/22 ~ 2009/04/30。
  1. 行政院衛生署中藥委員會計畫
  • 中藥製程開發機制－中藥酒劑產品長期服用或過量可能造成中毒來源之評估，CCMP95-CP-010，95年度。
  • 提昇中藥製劑之安全性研究及教育推廣－中藥藥酒長期服用造成中毒來源之安全性評估，CCMP94-CP-013，94年度。
  1. 產學合作計畫
  • (計畫主持人) 腱鞘炎治療之藥物載體-水膠系統開發，主持人，金額：1,111,111 NTD，2023/12/01-2024/11/30。
  • 台灣特有種愛玉萃取物活性開發，慧穎應用生物科技有限公司，2022/06/15 ~ 2022/12/31。
  • 一種烏魚材料的研究，海昇水產有限公司，2022/01/01 ~ 2022/12/31。
  • 魚腥草之指標成分分析，慧穎應用生物科技有限公司，2021/11/01 ~ 2022/04/30。
  • 一種天然植物之成分分離與鑑定，喬志亞生技股份有限公司，2020/05/01 ~ 2021/12/31。
  • 一種面膜之開發，南六企業股份有限公司，2020/12/15 ~ 2021/12/15。
  • 洛神子活性成分及精華萃取最佳化製程，慧穎應用生物科技有限公司，2020/11/01 ~ 2021/07/31。
  • 燈心草Juncus effusus抗氧化與抗瘇瘤活性成分開發，奇美醫療財團法人奇美醫院，2014/05/01 ~ 2015/04/30。
  • 台灣本土天然綠色製程萃取物-抗代謝症候群超臨界香椿萃取物產品研發計畫，慧穎應用生物科技有限公司，2012。
  • 薑萃取物活性測試，港香蘭應用生技，2008/12/01 ~ 2010/05/31。
  • 台灣栽培種特用植物丹參化學生物活性圖資(profiles)之研究計畫，玉富生物科技股份有限公司，2009。
  • 香柚及左手香相關產品之活性篩選，杏輝藥品工業股份有限公司，2008。

wink近五年研討會論文發表

  1. The 145th Annual Meeting of the Pharmaceutical Society of Japan, Fukuoka, Japan, March 26-29, 2025. “28-Day Repeated-Dose Oral Toxicity Assessment of Toona sinensis Extract in Rats.”  蔡逸宏*、柯佑民、吳志中、王惠君、葉明倫、朱恩良、余思穎、劉瓊惠、胡皓竣、劉怡旻、方家柔、陳依廷、吳友馨、李芷榆、吳東穎、楊家棟*、余明隆*、張芳榮*。
  2. The 54th Annual Meeting and Symposium of the Taiwan Association for Food Science and Technology, 2024. Taiwan Association for Food Science and Technology, New Taipei, Taiwan, November 29-December 1st, 2024. “Study on the Enhancement of Probiotic Flavor Sensory Evaluation Using Fruit Juice Powder and Acidulants.”曾泰瑞、吳金享、李岳賓、李岳桓、丘錦朋、杜英齊、賴宥捷、  張文凱、傅學偉、廖鼎魁、蔡逸宏*。
  3. Joint Symposium of the 39th SNP and 24th SFRR-Taiwan, 2024 -Cutting Edge, Translation and Application. The Society of Chinese Natural Medicine/The Society for Free Radical Research-Taiwan (SFRR-Taiwan), Taoyuan, Taiwan, October 04-06, 2024. “Natural resource transformation and innovation: The development of skin health conditioning and treatment agents from Coix agricultural by-products.” 蔡逸宏*、劉瓊惠、張芳榮、羅怡卿、張學偉、胡皓竣、余思穎、丘錦朋、劉怡旻、柯佑民、黃品嘉、王昱喬、洪嘉妤、蕭詠禎、 顏慈安、林子恩。
  4. The 38th Symposium on Natural Products—Insights into Natural Products from History & Symposium on Pharmacy and Traditional Chinese Medicine Presentation, 2023. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 27-29, 2023. “Advanced chemical and biological investigation of natural products from Andraca theae droppings.” 林淑晴、陳淑莉、楊美珠、蘇增成、黃聰龍、王士維、蔡逸宏*、張芳榮*。
  5. The 38th Symposium on Natural Products—Insights into Natural Products from History & Symposium on Pharmacy and Traditional Chinese Medicine Presentation, 2023. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 27-29, 2023. “Quality and production enhancement of fish mint, Houttuynia cordata Thunb., cultivated in a hydroponic planting system with designed plant growth-promoting additives.” 蔡逸宏#、盧燕奇、黃品嘉、謝震、謝慧萍、陳彥彰、陳雪娥、劉怡旻、廖家慶、張芳榮*。
  6. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Composition decipherment of Ficus pumila var. awkeotsang and its potential on COVID-19 symptom amelioration and in silico prediction of SARS-CoV-2 interference.” 胡皓竣、余思穎、黃筱珊、蘇俊翰、楊玉良、魏千凱、鄭源斌、吳永昌、顏嘉宏、黃聰龍、陳淑莉、István Szatmári、Attila Hunyadi、蔡逸宏*、張芳榮*。
  7. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Analysis on Chemical Constituents of Taiwanese Reynoutria multiflora (Thunb.) Moldenke.” 楊悅, 尹采晴、余思穎、胡皓竣、蔡逸宏、黃聰龍、廖家慶、陳淑莉、張芳榮*。
  8. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L.” 胡皓竣1、蔡逸宏1、吳光恆、莊友哲、郭宇廷、黃聰龍、Ferenc Fülöp、吳永昌、張芳榮*。
  9. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Development on potential skin anti-aging agents of Cosmos caudatus Kunth via inhibition of collagenase, MMP-1 and MMP-3 activities.” 盧燕奇、胡皓竣、余思穎、蔡逸宏、Michal Korinek、吳永昌、張芳榮*, 陳瑩容*。
  10. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “Decoding Multiple Biofunctions of Maca on Its Anti-allergic, Anti- inflammatory, Anti-thrombotic, and Pro-angiogenic Activities.” Kartiko Arif Purnomo、Michal Korinek、蔡逸宏、胡皓竣、王怡璇、Anders Backlund, 黃聰龍、陳炳宏、王士維、吳志中、張芳榮*。
  11. The 37th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2022. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 21-23, 2022. “The Enhancing Effects of Water Extract of Guilu Erxian Jiao on Skeletal Muscle Mass and Function in C57BL/6J mice.” 張婉瑄、方維宇、蔡逸宏、張芳榮、羅怡卿*。
  12. The 36th Symposium on Natural Products & Symposium on Traditional Chinese Medicine and Pharmacy, 2021. The Society of Chinese Natural Medicine, Kaohsiung, Taiwan, October 15-16, 2021. “Anti-allergic macapyrrolidones and macapyrrolins from maca explored through ChemGPS-NP.” Kartiko Arif Purnomo、Michal Korinek、蔡逸宏、胡皓竣、Anders Backlund、陳炳宏、張芳榮。
  13. The 35th Symposium of Natural Product and the 3rd Dr. Tsung Ming Tu medical forum, 2020. The Society of Chinese Natural Medicine, Taipei, Taiwan, September 11-13, 2020. “Bioactive components from Epicoccum sorhinum.” 張靜佳, 李其穎, 魏千凱, 蔡逸宏, 吳永昌, 黃聰龍, 吳志中, 王士維, 張芳榮。
  14. The 34th Symposium of Natural Products 2019., The Society of Chinese Natural Medicine, Taoyuan, Taiwan, October 17-19, 2019. “Chemical constituents and bioactivities from the roots of Physalis peruviana.” 林玉麒, 姚博議, 蔡逸宏, 胡皓竣, 黃聰龍, 張芳榮, 鄭源斌。
  15. “Acylated flavonoid glycosides from the twigs and leaves of Gleditsia rolfei and Their Anti-influenza Activity.” 楊子頡, 蔡逸宏, 顏嘉宏, 張芳榮。
  16. “Research on the chemical constituents and bioactivities of Epicoccum sorghinum isolated from Arundo donax L.” 張靜佳, 李其穎, 魏千凱, 蔡逸宏, 吳永昌, 黃聰龍, 吳志中, 王士維, 張芳榮。
  17. PSE-Young Scientists' Meeting 2019., Phytochemical Society of Europe, Budapest, June 19-22, 2019. “Development of traditional complex formulas as therapeutic agents.”蔡逸宏、曾予婷、吳東穎、羅怡卿*、張芳榮*。
  18. American Society of Pharmacognosy 2019 Annual Meeting, Madison, Wisconsin, July 13-17, 2019. “Chemical and biological investigation of natural products from Epicoccum sorghinum.” 張芳榮*、張靜佳、李其穎、蔡逸宏、魏千凱。
  19. The 17th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), Kuching-Sarawak, Malaysia, August 8-10, 2018. “Deciphers on the Chemical Constituents and Biological Activities of the Fruiting Body of Cordyceps militaris.” 丘錦朋、蔡逸宏、張芳榮。

 

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