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Journal Papers

1. Chen LC, Ma JW, Shieh PC, Horng CT. Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets. Pharmaceuticals (Basel).2020 Oct 23;13(11):E336.
2. Liu YS, Lu NH, Shieh PC, Sun CK. Combination of a Self-Regulation Module and Mobile Application to Enhance Treatment Outcome for Patients with Acne. Medicina (Kaunas). 2020 Jun 4;56(6):276.
3. Agoramoorthy G, Hsu MJ, Shieh P. Queries on the COVID-19 quick publishing ethics. Bioethics. 2020 Jul;34(6):633-634.
4. Masaru Takeuchi, Shieh PC, Horng CT. Treatment of Symptomatic Vitreous Opacities with Pharmacologic Vitreolysis Using a Mixure of Bromelain, Papain and Ficin Supplement. Appl. Sci. 2020, 10(17), 5901.
5. Shih-Huang Tai, Ping-Chung Kuo, Sio Hong Lam, Shiow-Chyn Huang, Yi-Zhuan Kuo,   Hsin-Yi Hung, Meei-Jen Liou, Po-Chuen Shieh, E.-Jian Lee and  Tian-Shung Wu.  Chemical constituents from the stems of Machilus philippinensis Merr. and the neuroprotective activity of cinnamophilin. RSC Adv., 2019, 9, 21616.
6. Chi-Ting Horng, Fu-An Chen, +4 authors P. Shieh. Pharmacologic vitreolysis of vitreous floaters by 3-month pineapple supplement in Taiwan : a pilot study. Published 2019.
7. Hung HY, Hung CC, Liang JW, Chen CF, Chen HY, Shieh PC, Kuo PC, Wu TS.Constituents and Anti-Multidrug Resistance Activity of Taiwan ofungus Camphoratus on Human Cervical Cancer Cells. Molecules. 2019 Oct 16;24(20):3730.
8. Wu CT, Deng JS, Huang WC, Shieh PC, Chung MI, Huang GJ. Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling. Oxid Med Cell Longev. 2019 May 12;2019:9056845.
9. Lu T, Liang WZ, Hao LJ, Kuo CC, Shieh P, Chou CT, Jan CR. Action ofchlorzoxazone on Ca²⁺ movement and viability in human oral cancer cells. Chin J Physiol. 2019 May-Jun;62(3):123-130.
10. Shieh P, Jan CR, Liang WZ. The protective effects of the antioxidant N-acetylcysteine (NAC) against oxidative stress-associated apoptosis evoked by the organophosphorus insecticide malathion in normal human astrocytes. Toxicology. 2019 Apr 1;417:1-14.
11. Wang JL, Chou CT, Liang WZ, Wu CJ, Kuo CC, Hao LJ, Shieh P, Jan CR. Effects of timolol on Ca²⁺ handling and viability in human prostate cancer cells. Toxicol Mech Methods. 2019 Feb;29(2):138-145.
12. Chiang SR, Lin CS, Lin HH, Shieh PC, Kao SH. Bergapten induces G1 arrest of non‑small cell lung cancer cells, associated with the p53‑mediated cascade. Mol Med Rep. 2019 Mar;19(3):1972-1978.
13. Chin HK, Horng CT, Liu YS, Lu CC, Su CY, Chen PS, Chiu HY, Tsai FJ, Shieh PC, Yang JS. Kaempferol inhibits angiogenic ability by targeting VEGF receptor-2 and downregulating the PI3K/AKT, MEK and ERK pathways in VEGF-stimulated human umbilical vein endothelial cells. Oncol Rep. 2018 May;39(5):2351-2357.
14. Hsien‑Kuo Chin, Chi‑Ting Horng, Yi‑Shan Liu, Chi‑Cheng Lu, Chen‑Ying Su, Pei‑Syuan Chen, Hong‑Yi Chiu, Fuu‑Jen Tsai, Po‑Chuen Shieh, Jai‑Sing Yang. Kaempferol inhibits angiogenic ability by targeting VEGF receptor-2 and downregulating the PI3K/AKT, MEK and ERK pathways in VEGF-stimulated human umbilical vein endothelial cells. ONCOLOGY REPORTS. 2018 (39) 2351-2357.
15. Tikhomirov AS, Shtil AA, Shchekotikhin AE. Advances in the Discovery of Anthraquinone-Based Anticancer Agents. Recent Pat Anticancer Drug Discov.2018;13(2):159-183.
16. Ching-Hsiang Wu, Po-Chuen Hsieh, F. Pan. How perceived threats of air pollution affect the residents purchasing behavior of functional foods. Journal of Asian Business Strategy. 2017
17. Horng CT, Chou CT, Sun TK, Liang WZ, Kuo CC, Wang JL, Shieh P, Jan CR. Effect of Carvacrol on Ca²⁺ Movement and Viability in PC3 Human Prostate Cancer Cells. Chin J Physiol. 2017 Oct 31;60(5):275-283.
18. Cheng HH, Chou CT, Liang WZ, Kuo CC, Shieh P, Wang JL, Jan CR. Effect of Protriptyline on [Ca²⁺]i and Viability in MDCK Renal Tubular Cells. Chin J Physiol. 2017 Apr 30;60(2):114-123.
19. Wu MH, Lee TH, Lee HP, Li TM, Lee IT, Shieh PC, Tang CH. Kuei-Lu-Er-Xian-Jiao extract enhances BMP-2 production in osteoblasts. Biomedicine (Taipei). 2017 Mar;7(1):2.
20.  Yeh JH, Chou CT, Chen IS, Lu T, Lin KL, Yu CC, Liang WZ, Chang HT, Kuo CC,Ho CM, Chang WT, Shieh P, Jan CR. Effect of thymol on Ca²⁺ homeostasis and viability in PC3 human prostate cancer cells. Chin J Physiol. 2017 Feb 28;60(1):32-40.
21. Cheng HH, Chou CT, Liang WZ, Cheng JS, Chang HT, Kuo CC, Chen IS, Lu T, Yu CC, Chen FA, Kuo DH, Shieh P, Jan CR. Effect of NPC15199 on [Ca²⁺]i and viability in SCM1 human gastric cancer cells. Chin J Physiol. 2016 Oct 31;59(5):268-275.
22. Su CK, Chou CT, Lin KL, Liang WZ, Cheng JS, Chang HT, Chen IS, Lu T, Kuo CC,Yu CC, Shieh P, Kuo DH, Chen FA, Jan CR. Effect of protriptyline on [Ca²⁺]_i and viability in MG63 human osteosarcoma cells.Toxicol Mech Methods. 2016 Oct;26(8):580-587.
23. Chang HT, Chou CT, Chen IS, Yu CC, Lu T, Hsu SS, Shieh P, Jan CR, Liang WZ.Mechanisms underlying effect of the mycotoxin cytochalasin B on induction of cytotoxicity, modulation of cell cycle, Ca²⁺ homeostasis and ROS production in human breast cells. Toxicology. 2016 Aug 31;370:1-19.
24. Shen DY, Kuo PC, Huang SC, Hwang TL, Chan YY, Shieh PC, Ngan NT, Thang TD,Wu TS. Constituents from the leaves of Clausena lansium and their anti-inflammatory activity. J Nat Med. 2017 Jan;71(1):96-104.
25. Lee HH, Chou CT, Liang WZ, Chen WC, Wang JL, Yeh JH, Kuo CC, Shieh P, Kuo DH, Chen FA, Jan CR. Ca²⁺ Movement Induced by Deltamethrin in PC3 Human Prostate Cancer Cells. Chin J Physiol. 2016 Jun 30;59(3):148-55.
26. Chen IS, Chou CT, Liu YY, Yu CC, Liang WZ, Kuo CC, Shieh P, Kuo DH, Chen FA,Jan CR. The investigation of minoxidil-induced [Ca²⁺] _irises and non- Ca²⁺-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2017 Feb;37(1):1-7.
27. Wang JL, Chou CT, Liu K, Liang WZ, Cheng JS, Chang HT, Chen IS, Lu T, Kuo CC, Yu CC, Shieh P, Kuo DH, Chen FA, Jan CR. Ca²⁺ Signaling and Cell Death Induced by Protriptyline in HepG2 Human Hepatoma Cells. J Biochem Mol Toxicol. 2016 Nov;30(11):539-547.
28. Wang JL, Chou CT, Liang WZ, Yeh JH, Kuo CC, Lee CY, Shieh P, Kuo DH, Chen FA, Jan CR. Effect of 2,5-dimethylphenol on Ca(2+) movement and viability in PC3 human prostate cancer cells. Toxicol Mech Methods. 2016 Jun;26(5):327-33.
29. Hsu SS, Chou CT, Liao WC, Shieh P, Kuo DH, Kuo CC, Jan CR, Liang WZ. The effect of gallic acid on cytotoxicity, Ca(2+) homeostasis and ROS production in DBTRG-05MG human glioblastoma cells and CTX TNA2 rat astrocytes. Chem Biol Interact. 2016 May 25;252:61-73.
30. Liang WZ, Chou CT, Cheng JS, Wang JL, Chang HT, Chen IS, Lu T, Yeh JH, Kuo DH, Shieh P, Chen FA, Kuo CC, Jan CR. The effect of the phenol compound ellagic acid on Ca(2+) homeostasis and cytotoxicity in liver cells. Eur J Pharmacol. 2016 Jun 5;780:243-51.
31. Cheng JS, Chou CT, Liu YY, Sun WC, Shieh P, Kuo DH, Kuo CC, Jan CR, Liang WZ. The effect of oleuropein from olive leaf (Olea europaea) extract on Ca²⁺ homeostasis, cytotoxicity, cell cycle distribution and ROS signaling in HepG2 human hepatoma cells. Food Chem Toxicol. 2016 May;91:151-66.
32. Shih HC, Kuo PC, Wu SJ, Hwang TL, Hung HY, Shen DY, Shieh PC, Liao YR, Lee EJ, Gu Q, Lee KH, Wu TS. Anti-inflammatory neolignans from the roots of Magnolia officinalis. Bioorg Med Chem. 2016 Apr 1;24(7):1439-45.
33. Chien KJ, Huang HW, Huang TC, Lee CL, Weng KP, Lin CC, Shieh PC, Wu MT, Hsieh KS. Assessment of branch pulmonary artery stenosis in children after repair of tetralogy of Fallot using lung perfusion scintigraphy comparison with echocardiography. Ann Nucl Med. 2016 Jan;30(1):49-59.
34. Roan CJ, Chou CT, Liang WZ, Chang HT, Kuo DH, Kuo CC, Chen FA, Shieh P, Jan CR. Effect of Miconazole on [Ca²⁺]i and Cytotoxicity in ZR-75-1 Human Breast Cancer Cells. Chin J Physiol. 2015 Dec 31;58(6):377-84.
35. Kuan-Yun Chen, Chih-Yang Lin, Chun-Jun Yang, Sen Yang, Po-Chuen Shieh, Chih-Hsin Tang. Effects of WISP-1 on Matrix Metalloproteinase Expression and Wound Healing in Human Skin Fibroblasts via Down-Regulation of miR-519d. 調適醫學.  (7) 2015  P202 - 209.
36. Ma GH, Lin CW, Hung HY, Wang SY, Shieh PC, Wu TS. New Benzenoids from the Roots of Lindera aggregata. Nat Prod Commun. 2015 Dec;10(12):2131-3.
37. Hung TY, Chou CT, Sun TK, Liang WZ, Cheng JS, Fang YC, Li YD, Shieh P, Ho CM, Kuo CC, Lin JR, Kuo DH, Jan CR. The Mechanism of Safrole-Induced [Ca²⁺]i Rises and Non-Ca²⁺-Triggered Cell Death in SCM1 Human Gastric Cancer Cells. Chin J Physiol. 2015 Oct 31;58(5):302-11.
38. Li YD, Chou CT, Liang WZ, Tseng HW, Fang YC, Hung TY, Chang HT, Kuo DH, Kuo CC, Ho CM, Shieh P, Chen FA, Jan CR. Effect of NPC-14686 (Fmoc-l-Homophenylalanine) on Ca²⁺ Homeostasis and Viability in OC2 Human Oral Cancer Cells. Chin J Physiol. 2015 Oct 31;58(5):285-93.
39. Chang HT, Chou CT, Lin YS, Shieh P, Kuo DH, Jan CR, Liang WZ. Esculetin, a natural coumarin compound, evokes Ca(2+) movement and activation of Ca(2+)-associated mitochondrial apoptotic pathways that involved cell cycle arrest in ZR-75-1 human breast cancer cells. Tumour Biol. 2016 Apr;37(4):4665-78.
40. Fang HW, Liao YR, Hwang TL, Shieh PC, Lee KH, Hung HY, Wu TS. Total synthesis of cordatanine, structural reassignment of drymaritin, and anti- inflammatory activity of synthetic precursors. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3822-4.
41. Chang HT, Chou CT, Kuo DH, Shieh P, Jan CR, Liang WZ. The Mechanism of Ca(2+) Movement in the Involvement of Baicalein-Induced Cytotoxicity in ZR-75-1 Human Breast Cancer Cells. J Nat Prod. 2015 Jul 24;78(7):1624-34.
42. Lu T, Chou CT, Liang WZ, Yu CC, Chang HT, Kuo CC, Chen WC, Kuo DH, Ho CM, Shieh P, Jan CR. Effect of Antidepressant Doxepin on Ca²⁺ Homeostasis and Viability in PC3 Human Prostate Cancer Cells. Chin J Physiol. 2015 Jun 30;58(3):178-87.
43. Yeh JH, Sun TK, Chou CT, Chen WC, Lee JK, Yeh HC, Liang WZ, Kuo CC, Shieh P,Kuo DH, Jan CR. Effect of sertraline on Ca²⁺ fluxes in rabbit corneal epithelial cells. Chin J Physiol. 2015 Apr 30;58(2):85-94.
44. Horng CT, Chou CT, Tseng HW, Cheng JS, Chang HT, Chang PM, Chen IL, Hung MC,Tsai YJ, Tsai PC, Liang WZ, Kuo CC, Kuo DH, Ho CM, Lin JR, Shieh P, Jan CR.Effect of methoxychlor on Ca²⁺ homeostasis and apoptosis in HA59T human hepatoma cells. Chin J Physiol. 2015 Feb 28;58(1):1-8.
45. Chien JM, Chou CT, Liang WZ, Cheng JS, Chang HT, Tseng HW, Kuo SY, Kuo CC,Chen FA, Shieh P, Ho CM, Lin JR, Kuo DH, Jan CR. Effect of deoxycholic acid on Ca2+ movement, cell viability and apoptosis in human gastric cancer cells. Toxicol Mech Methods. 2015 Feb;25(2):113-9.
46. Chang HT, Chou CT, Yu CC, Tsai JY, Sun TK, Liang WZ, Lin KL, Tseng HW, Kuo CC, Chen FA, Kuo DH, Pan CC, Ho CM, Shieh P, Jan CR. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34.
47. Liu FJ, Chou CT, Cheng JS, Chang HT, Liang WZ, Kuo CC, Kuo SY, Kuo DH, Shieh P, Chang FR, Jan CR. Ca(2+) movement and apoptosis induced by deltamethrin in Madin-Darby canine kidney canine renal tubular cells. Kaohsiung J Med Sci. 2015 Jan;31(1):1-8.
48. Liang WZ, Chou CT, Hsu SS, Liao WC, Shieh P, Kuo DH, Tseng HW, Kuo CC, Jan CR. The involvement of mitochondrial apoptotic pathway in eugenol-induced cell death in human glioblastoma cells. Toxicol Lett. 2015 Jan 5;232(1):122-32.

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