吳姿慧 副教授       辦公室：U725     分機： 2725       

政府、產學及校內計畫:

1.  上浤醫藥生技股份有限公司產學合作計畫: 寵物保健食品科學驗證與適口性評估之商品化應用研究/600,000元/2026/06/15~2027/07/14/計畫主持人
2.  大學社會責任實踐基地(USR HUB)種子計畫:大仁大愛共創同心-科普教育 × 弱勢支持 × 永續開發/450,000元/2026/01/01~2026/12/31/共同計畫主持人
3.  國家科學委員會/牛蒡苷元及其奈米顆粒做為抗污染皮膚保養成分之機制研究/ 4,532,000元 /2025/08/01~2026/07/31/共同主持人
4.  國家科學委員會/蝶豆花及其農作廢棄物的萃取物在化粧品產品開發研究/ 2,178,365元/2024/06/01~2025/08/31/共同主持人
5.  國家科學委員會/以in silico和in vitro方法探討紫檀芪衍生物傳遞體保護空氣汙染物引起的角質細胞損傷分子生物機制/ 4,044,074元2024/08/01~2025/07/31/共同主持人
6.  大學社會責任實踐基地(USR HUB)種子計畫: 大仁大愛共榮共好偏鄉教育 x 人才培育 x 永續經營/300,000元/2025/0101~2025/1231/計畫主持人
7.  大學社會責任實踐基地(USR HUB)種子計畫:藥善護生永續扎根STEAM教育暨創新人才培育計畫/300,000元/2023/0101~2024/1231/計畫主持人
8.  大樹寵物產學合作計畫：皮膚保健及貓用營養粉寵物保健食品開發案/330,000元/2022/1201~2024/1231/計畫主持人

技術利轉：

1. 本實驗室開發「楊梅素速溶粉」技術轉移芳圓有限公司 2025/07 至 2030/06

 發表期刊

1.  Wu, T.-H., Lan, Y.-Y., Hsu, H.-E., So, P. B., Chen, Y.-Y., & Yen, F.-L. (2025). Hesperetin nanoparticle powder as a potential antioxidant nutraceutical ingredient: Fabrication, characterization, and comparative dissolution in vegetarian and non-vegetarian capsules. Pharmaceutics, 17, 1558.
2.  Fu, H., Yang, C.-Y., So, P. B., Yen, C.-H., Wu, T.-H.*, & Yen, F.-L. (2025). Assessment of skin safety and anti-pollution activity of Clitoria ternatea L. (butterfly pea) flower extract. Journal of Ethnopharmacology, 356, 120739.
3.  So, P. B., Wang, Y.-C., Huang, P.-H., Wu, T.-H., & Yen, F.-L. (2025). Physicochemical characterization, skin penetration, anti-melanogenesis and safety assessment of flavokawain C nanofibers. International Journal of Molecular Sciences, 26(7), 2966.
4.  Fu, H., Wu, T.-H., Ma, C.-P., & Yen, F.-L. (2024). Improving water solubility and skin penetration of ursolic acid through a nanofiber process to achieve better in vitro anti-breast cancer activity. Pharmaceutics, 16(9), 1147.
5.  Lin, T.-C., Yang, C.-Y., Wu, T.-H., Tseng, C.-H., & Yen, F.-L. (2023). Myricetin nanofibers enhanced water solubility and skin penetration for increasing antioxidant and photoprotective activities. Pharmaceutics, 15(3), 906.
6.  Tran, H. M., Yang, C.-Y., Wu, T.-H.*, & Yen, F.-L. (2022). Liposomes encapsulating morin: Investigation of physicochemical properties, dermal absorption improvement and anti-aging activity in PM-induced keratinocytes. Antioxidants, 11(6), 1183.
7.  Cham, T. M., Wu, T.-H., Tsai, T.-R., Huang, Y.-T., & Chuo, W.-H.* (2012). Statistical optimization of novel traditional Chinese medicine (Liu-Wei-Di-Huang-Wan) pellets prepared by extrusion-spheronization method. Journal of Food and Drug Analysis, 20, 908–921.
8.  Lee, C. W., Yen, F.-L., Huang, H.-W., Wu, T.-H., Ko, H. H., Tzeng, W. S., & Lin, C. C. (2012). Resveratrol nanoparticle system improves dissolution properties and enhances the hepatoprotective effect of resveratrol through antioxidant and anti-inflammatory pathways. Journal of Agricultural and Food Chemistry, 60(18), 4662–4671.
9. Hsu, W. C., Ng, L. T., Wu, T.-H., Lin, L. T., Yen, F.-L., & Lin, C. C. (2012). Characteristics and antioxidant activities of silymarin nanoparticles. Journal of Nanoscience and Nanotechnology, 12(3), 2022–2027.
10.  Tzeng, C. W., Yen, F.-L., Wu, T.-H., Ko, H. H., Lee, C. W., Tzeng, W. S., & Lin, C. C.* (2011). Enhancement of dissolution and antioxidant activity of kaempferol using a nanoparticle engineering process. Journal of Agricultural and Food Chemistry, 59(9), 5073–5080.
11.  Yen, F.-L., Wu, T.-H., Tzeng, C. W., Lin, L. T., & Lin, C. C.* (2010). Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. Journal of Agricultural and Food Chemistry, 58(12), 7376–7382.
12. Yen, F.-L., Wu, T.-H., Lin, L. T., Cham, T. M., & Lin, C. C.* (2009). Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally administered rats with CCl₄-induced acute liver failure. Pharmaceutical Research, 26(4), 893–902.
13.  Yen, F.-L., Wu, T.-H., Lin, L. T., Cham, T. M., & Lin, C. C.* (2008). Nanoparticle formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats. Food and Chemical Toxicology, 46(5), 1771–1777.
14.  Yen, F.-L., Wu, T.-H., Lin, L. T., Cham, T. M., & Lin, C. C.* (2008). Concordance between antioxidant activities and flavonol contents in different extracts and fractions of Cuscuta chinensis. Food Chemistry, 108(2), 455–462.
15.  Wu, T.-H., Yen, F.-L., Lin, L. T., Tsai, T.-R., Lin, C. C., & Cham, T. M.* (2008). Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles. International Journal of Pharmaceutics, 346(1–2), 160–168.
16.  Yen, F.-L., Wu, T.-H., Lin, L. T., & Lin, C. C.* (2007). Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats. Journal of Ethnopharmacology, 111(1), 123–128.
17.  Yen, F.-L., Wu, T.-H., Liao, C. W., & Lin, C. C.* (2007). A Kampo medicine, Yin-Chiao-San, prevents bleomycin-induced pulmonary injury in rats. Phytotherapy Research, 21(3), 251–258.

指導研究生：

1. 許懷恩（2026，碩士班）
   　學校／系所： 大仁科技大學藥學系碩士班
   　論文題目： Fisetin/HPβCD 速溶粉製劑開發與聚合物篩選研究
   　指導教授： 吳姿慧
2. 吳淑卿（2025，碩士在職專班）
   　學校／系所： 大仁科技大學藥學系碩士在職專班
   　論文題目： 中草藥益生菌應用於貓齦口炎併病毒感染之輔助療法－案例研究
   　指導教授： 吳姿慧
3.  沈純如（2025，碩士在職專班）
   　學校／系所： 大仁科技大學藥學系碩士在職專班
   　論文題目： 嚴重特殊傳染性肺炎疫情對高雄仁大工業區附近某健保藥局慢性處方箋之影響評估
   　指導教授： 吳姿慧、顏峰霖（共同指導）
4. 許青育（2025，碩士在職專班）
   　學校／系所： 大仁科技大學藥學系碩士在職專班
   　論文題目： 臺灣地區藥師執行戒菸服務計畫之工作滿意度及工作壓力研究
   　指導教授：吳姿慧、郭代璜（共同指導）

藥師國家考試題庫彙編：

1. 《藥事行政與法規（第四版）》國家考試試題（107–114 年）
   　編著單位：大仁科技大學
   　作者：吳姿慧、黃煒忠、陳垣佑、趙芩、馬松佑、蔡羽婷。
2. 《藥劑學（第二版）》國家考試試題（104–114 年）
   　編著單位：大仁科技大學
   　作者：李宜庭、卓玟禾、吳姿慧。

U736實驗室成員：